Studying at York
Advanced Topics in Molecular Biology - BIO00071H
Module summary
Eukaryotes use multiple interconnected regulatory mechanisms to control gene expression. The module will provide a current understanding of some of these mechanisms through lectures supported by analysis and discussion of research literature and workshops. Topics that are likely to be addressed include: How nuclear architecture influences gene expression; how transcription is coupled with other cellular processes; how the coding capacity of genomes is increased through alternative splicing and RNA editing; mechanisms of regulation by non-coding RNAs; parasite regulatory mechanisms; the consequences when gene expression control mechanisms are defective. The mechanisms will be considered at the molecular level in a range of biological contexts.
Related modules
Pre-requisite modules
Co-requisite modules
- None
Prohibited combinations
- None
Module will run
| Occurrence | Teaching period |
|---|---|
| A | Autumn Term 2022-23 to Summer Term 2022-23 |
Module aims
Eukaryotes use multiple interconnected regulatory mechanisms to control gene expression. The module will provide a current understanding of some of these mechanisms through lectures supported by analysis and discussion of research literature and workshops. Topics that are likely to be addressed include: How nuclear architecture influences gene expression; how transcription is coupled with other cellular processes; how the coding capacity of genomes is increased through alternative splicing and RNA editing; mechanisms of regulation by non-coding RNAs; parasite regulatory mechanisms; the consequences when gene expression control mechanisms are defective. The mechanisms will be considered at the molecular level in a range of biological contexts.
Module learning outcomes
1: Explain molecular mechanisms by which eukaryotic gene expression can be controlled and discuss how they are inter-connected
2: Evaluate experimental evidence that supports key developments in the field of eukaryotic gene expression
3: Analyze, interpret and make conclusions from novel data from research articles and use this knowledge to add detail to your understanding of gene expression pathways
4: Devise experimental strategies to address questions related to gene expression
Indicative assessment
| Task | % of module mark |
|---|---|
| Online Exam - 24 hrs (Centrally scheduled) | 100 |
Special assessment rules
None
Indicative reassessment
| Task | % of module mark |
|---|---|
| Online Exam - 24 hrs (Centrally scheduled) | 100 |
Module feedback
Cohort-level feedback will be provided on performance in closed exams and made available via the VLE. Histograms of module marks will be posted on the notice boards outside the Biology Student Services office. Individual marks will be made available to you and your supervisor via e:vision. Exam scripts will be made available at the end of either the Spring or Summer terms. You should take the opportunity to discuss your marks and feedback with your supervisor.
During the teaching of the module you will receive feedback that may be at a whole class or individual level. Forms of feedback may include: model answers and discussion of workshop questions, summaries of performance in practicals, VLE-based quizzes, individual spoken comments during workshops, individual written comments on formative work.
Indicative reading
These are available through the VLE module site.