PLAZZMID is a novel flexible and extensible computational framework and toolset inspired by sophisticated models of complex biological evolutionary processes that occur in bacteria and in bees. The tools will be able to be used both to build and analyse testable models of biological evolutionary processes, and to build and analyse powerful novel computational metaphors and algorithms based on these more sophisticated biological models. Within the research project, the tools will be used in a series of theoretical biological experiments on the relationship between genome structure and evolvability, and used to evolve computational systems exhibiting complex homeostatic control in a changing environment.