Fundamentals of Chemistry for Biochemists 1 - CHE00031C
Module summary
This foundation chemistry course builds on the chemistry learned at A level or an equivalent grade. The course begins with a lecture course on Structure, Bonding & Equilibria including principles of acid and base chemistry. Organic molecules and their reactions are introduced with a focus on reaction mechanism, and important classes of organic molecules, aromatics and carbonyls, are studied in detail. The module includes an introductory thermodynamics for biochemistry and biomolecules.
Module will run
| Occurrence | Teaching period |
|---|---|
| A | Semester 1 2023-24 |
Module aims
This module aims, together with the Fundamentals of Chemistry for Biochemists II, to provide Biochemistry students with a foundation course in Chemistry. The materials presented, which cover Structure, Bonding & Equilibria, Biochemical Thermodynamics, Organic Structures and Mechanisms, Aromatic Chemistry and Organic Carbonyls, are essential for developing an understanding of the structure and interactions of biological macromolecules and ligands, and provide the Biochemistry student with a foundation course in Chemistry. The course builds on A level Chemistry or its equivalent and forms a prerequisite for subsequent Chemistry modules specifically designed for the Biochemists.
Module learning outcomes
Students will be expected to be able to describe, understand and interpret
- the basic properties of acids, bases and chemical equilibria
- applications of thermodynamics to biochemistry
- the 3D structures of organic molecules and typical reaction pathways and mechanism types
- distinctive properties and reactivity of aromatic organic molecules and carbonyls
- basic structure and bonding theories to predict and understand molecular shape in organic and inorganic molecules
- the classification of stereochemistry in organic molecules
Module content
|
Biochemical Thermodynamics |
SS |
4h online materials+ 2 in-person problem-solving lectures + 2 h computer workshop + 2h college workshop |
|
Chemical Equilibria, Enthalpy, Entropy, Gibbs free energy, van't Hoff plot, Biochemical Models, Calorimetry and Data Analysis |
||
|
Structure & Bonding and Equilibria |
JML |
10 lectures + 1h workshop |
|
Bronsted acids and bases. pH, pKa, pKb, understanding titrations and amino acid structure. Chemistry of the elements of the first row in the periodic table (Li-F) through study of their compounds with hydrogen. Various primary and secondary bonding types, resulting in a wide range of molecular properties from reactive hydride salts through to highly inert gases and acidic and basic liquids. Electron pair approach to covalent bonding. Application to shape, stereoisomerism, bond energies and electronic effects in molecules. |
||
|
Organic Structures & Mechanisms |
GAH/DKS |
10 lectures + 1h tutorial + 1 workshop |
| Aromatic Chemistry and Organic Carbonyls | AFP |
8 lectures 1 tutorial |
Indicative assessment
| Task | % of module mark |
|---|---|
| Closed/in-person Exam (Centrally scheduled) | 100 |
Special assessment rules
Other
Indicative reassessment
| Task | % of module mark |
|---|---|
| Closed/in-person Exam (Centrally scheduled) | 100 |
Module feedback
-
Tutorials/workshops: Written feedback will be given for tutorial work within a week. Written and/or oral feedback for workshops will be given either during the sessions or within a week.
-
Exams: Closed exam results with per-question breakdown are returned to the students via supervisors within 5 weeks. Outline answers are made available via the Chemistry web pages when the students receive their marks, so that they can assess their own detailed progress/achievement. The examiners’ reports for each question are made available to the students via the Chemistry web pages.
Indicative reading
Burrows, Holman, Parsons, Pilling and Price: Chemistry3 (Oxford University Press)