Studying at York
Molecular Biology & Biochemistry - BIO00004C
Module will run
| Occurrence | Teaching period |
|---|---|
| A | Autumn Term 2022-23 to Summer Term 2022-23 |
Module aims
This module deals with the structure and function of fundamental chemical molecules of a cell. It starts with an overview of the module and advanced applications that depend on the subjects covered in the module. It then covers the basic chemical building blocks of cells, from elements to macromolecules. The structure of nucleic acids will be introduced, and its importance to the mechanism of DNA replication. Then, the different levels of protein structure will be defined and protein-protein interactions, covalent modification and the nature of membrane proteins, described. The functionality of proteins as enzymes will be discussed in detail. Following an introduction to lipid and carbohydrate structures, the role of the various macromolecules in the context of membrane flow, cell shape, cytoskeleton, etc. will be discussed. Energy and metabolism is introduced by discussing the important concept of free energy and relating this to the central role of ATP and coupling of biochemical processes. The course then surveys carbohydrate and fat metabolism, photosynthesis and related metabolic processes in plants, and concludes with section on the integration of metabolism.
Module learning outcomes
- To be able to describe the main chemical components of cells, their structural properties, how these relate to their functions, and how they are altered during cellular processes
- To be able to describe and explain how covalent and non-covalent interactions bring about the assembly of cellular components and macromolecules
- To be able to explain theoretical frameworks (such a Michaelis Menten kinetics, the laws of thermodynamics and the chemiosmotic theory) that allow us to understand function of biological molecules and cells
- To be able to integrate knowledge about heterotrophic metabolism (of carbohydrates & lipids) and phototrophic metabolism and how they relate to energy metabolism via ATP
- To be able to relate knowledge of biological molecules to health and disease and to their application in biotechnology
- To be able to apply quantitative approaches to perform basic calculations related to acid-base chemistry, redox reactions, and to analyse and evaluate enzyme kinetics data gathered in practical classes
Indicative assessment
| Task | % of module mark |
|---|---|
| Online Exam -less than 24hrs (Centrally scheduled) | 50 |
| Online Exam -less than 24hrs (Centrally scheduled) | 50 |
Special assessment rules
None
Indicative reassessment
| Task | % of module mark |
|---|---|
| Online Exam -less than 24hrs (Centrally scheduled) | 50 |
| Online Exam -less than 24hrs (Centrally scheduled) | 50 |
Module feedback
Cohort-level feedback will be provided on performance in closed exams and made available via the VLE. Histograms of module marks will be posted on the notice boards outside the Biology Student Services office. Individual marks will be made available to you and your supervisor via e:vision. Exam scripts will be made available at the end of either the Spring or Summer terms. You should take the opportunity to discuss your marks and feedback with your supervisor.
During the teaching of the module you will receive feedback that may be at a whole class or individual level. Forms of feedback may include: model answers and discussion of workshop questions, summaries of performance in practicals, VLE-based quizzes, individual spoken comments during workshops, individual written comments on formative work.
Indicative reading
These are available through the VLE module site.