ACTIVE – A RCT assessing the effectiveness of internal plate fixation versus external fine wire fixation for the management of Type C, closed pilon fractures of the distal tibia
DIDACT - Multi-centre randomised controlled trial to assess the effectiveness and cost-effectiveness of surgery compared with sling immobilisation in the management of adults with radiological diagnosis of a displaced fracture of the distal clavicle that does not involve the acromioclavicular joint.
DISC – A RCT comparing injections of collagenase to surgical correction in the treatment of moderate Dupuytren's contracture
FARSTER-Care - An RCT investigating whether, following cardiac surgery with full median sternotomy, an accelerated cardiac rehabilitation pathway will lead to improved patient outcomes and is cost effective compared to the usual timing of cardiac rehabilitation.
FLARE - A multi-centre, two-arm, non-inferiority, parallel group, randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study, to assess whether the repair of the Flexor Digitorum Profundus (FDP) alone results in a as good as quality of life compared to repairing FDP and the Flexor Digitorum Superficialis (FDS).
HAMLET - A multicentre, two-arm, non-blinded, pragmatic, parallel group, randomised controlled superiority trial assessing the clinical and cost effectiveness of Through Knee Amputation (TKA) compared to Above Knee Amputation (AKA) in patients requiring major lower limb amputations (MMLA), but who are unsuitable for a Below Knee Amputation (BKA).
MEASURE - A national, mixed-methods study to evaluate the impact of High-volume low-complexity surgical hubs in England.
PERISCOPE - What are the benefits and harms of continuation versus stoppage of biologics in patients with inflammatory arthritis (IA) undergoing orthopaedic surgery?
PROFHER-2 – A RCT assessing the effectiveness of Reverse Shoulder Arthroplasty versus Hemiarthroplasty versus Non-surgical care for acute three and four-part fractures of the proximal humerus in older adults
PROLLIT – A study to develop a Patient Reported Outcome Measure (PROM) for lower limb reconstruction
RAPSODI - An RCT assessing whether reverse total shoulder replacement is superior to an anatomical total shoulder replacement for the treatment of painful osteoarthritis of the shoulder joint in patients over 60 years old.
RESTART PD - A multicentre, two-arm, non-blinded, pragmatic, parallel group, randomised controlled superiority trial with the aim of assessing the clinical and cost effectiveness of Reality DTx®compared with traditional physiotherapy for patients with Parkinson’s Disease.
SCOOTT - A multi-centre, superiority and non-inferiority three-arm RCT to assess the clinical and cost effectiveness of treating arthritis of the base of the thumb, with or without surgery and to determine the clinical and cost effectiveness of trapeziectomy versus base of thumb joint replacement.
SOFFT – A non-inferiority RCT of fracture fixation for simple olecranon fractures in adults
Completed Projects
CaTS – a retrospective cohort study to identify current demographics and treatment pathways for calcific tendinitis
EVerT2 – An RCT of needling vs. nonsurgical debridement for the treatment of a Verruca
FARSTER – A mixed methods feasibility study of early outpatient review and early cardiac rehabilitation after coronary artery bypass grafting
KReBs – A RCT of the effect of a Two-layer Compression Bandage System on Knee Function following Total Knee Arthroplasty
L1FE – A RCT investigating the effectiveness of surgical fixation with INFIX compared to non-surgical management of LC-1 fragility fractures in older adults
OKIS – Orthotic management of instability of the knee in neuromuscular disease: systematic review, qualitative study, survey and costing analysis
OPAL – A feasibility study of Occupational advice for Patients undergoing Arthroplasty of the Lower limb to improve speed of recovery
OSTRICH – An RCT of the effectiveness of two types of orthotics for treatment of symptomatic flat feet in children
PERSONAL-EYE-S – A feasibility study of digitally printed versus hand-painted artificial eyes in adults
ProFHER – An RCT to evaluate the effectiveness of surgical versus non-surgical treatment for the majority of displaced fractures of the proximal humerus in adults
QIST – Avoiding surgical site infection and anaemia at the time of surgery using a quality improvement Collaborative model: an RCT
SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers
STEPFORWARD – Patient acceptability of a novel prosthetic device: a randomised feasibility study in older patients with vascular-related amputations and multi-morbidities
SWIFFT – An RCT to determine whether adults with a fracture of the scaphoid waist should receive plaster cast treatment or surgical fixation
UK FROST – A RCT comparing three treatments for patients referred to secondary care with a frozen shoulder
