EMPRESS – A study comparing the pathway to diagnosis as an emergency presentation compared to diagnosis via the 2WW pathway for lung and colorectal cancer
STRATEGIC – An RCT of interventions to increase cervical screening uptake at first invitation in young women
Cardiovascular
BreatheMOR-HF – An RCT to determine whether prescribing slow-release daily morphine tablets to individuals with heart failure helps with breathlessness
FARSTER – A mixed methods feasibility study of early outpatient review and early cardiac rehabilitation after coronary artery bypass grafting
HOT – an RCT of home oxygen therapy for patients with chronic heart failure
SEDRIC – Development and piloting of a structured education programme promoting self-managed walking exercise in patients with intermittent claudication
Education
5Rs RCT – evaluation of a maths programme for GCSE resits
ABRA – Abracadabra an RCT of an online literacy programme for Year 1 pupils
ASSSIST – A study to develop a manualised Social Stories intervention for use with children with autism spectrum disorder in mainstream schools to reduce challenging behaviour.
EasyPeasy – pre-school learning through play: a cluster RCT
EAL – An RCT of English as an Additional Language training for classroom teachers at GCSE
E-PLAYS – Enhancing Pragmatic LAnguage skills for Young children with Social communication disorder: a feasibility study
Grammar for Writing – An RCT to understand the effectiveness of Grammar for Writing at improving the writing skills of Year 6 pupils
LEXIA – A trial of the effectiveness of Lexia Reading CORE5, a computer-based independent learning system for struggling readers in Year 2
Maths Champions – a cluster RCT of an online programme in supporting nursery practitioners to develop numeracy skills for children aged 3-4 years
Project-Based Learning – An RCT of delivery of all lessons and activities around a single complex enquiry or project for Year 7
Project Teensleep – a pilot study of the impact of sleep education on students’ sleep
ReflectED – An RCT of the ReflectED approach to developing metacognition skills in KS1+2 pupils to support attainment in maths and reading
SCI-napse – A pilot study followed by a full-scale pragmatic RCT evaluating the impact of a game-based approach to whole class teaching on pupils’ learning.
Tutor Trust – An RCT of the effectiveness of the Tutor Trust tutoring programme for improving maths attainment at Key Stage 2 for children who are performing below expected norms
Year 5 Science – A multi-phase project to develop a Year 5 science attainment assessment for use as an evaluation outcome measure
Global Health
LEISH Sudan – A Phase IIa/IIb clinical trial to evaluate the therapeutic efficacy of ChAd63-KH vaccine in patients with persistent post kala-azar dermal leishmaniasis
MCLASS – Muslim Communities Learning About Second-hand Smoke: a cluster randomised controlled trial and cost-effectiveness analysis
MCLASS II – Muslim Communities Learning About Second-hand Smoke in Bangladesh: an effectiveness-implementation hybrid study
Mental Health and Addiction
ACUDep - A trial of acupuncture or counselling with usual care, compared to usual care alone for the treatment of depression.
ARiAS – A research programme investigating methods of improving the physical and mental health of people with alcohol and/or illicit drug addiction identified within an acute setting
CASPER – An RCT of the effectiveness of CollAborative care and active surveillance for Screen-Positive EldeRs with subthreshold depression
CASPER PLUS – An RCT of the effectiveness of screening and low intensity psychosocial interventions for people over 65 years with major depressive disorders
cCBT – A pilot study exploring the potential of computerised cognitive behavioural therapy (cCBT) amongst an adolescent population
CHAMP-1 – A 5-year programme to design and evaluate in an RCT an intervention to incorporate discussion of alcohol use in medication appointments
CHEMIST – Evaluating the delivery of brief psychological support via community pharmacies to people with long-term health conditions at an increased risk of developing dementia: a feasibility and pilot study
Connect – A cluster RCT of the effectiveness of a training programme for police officers who come into contact with people with mental health problems and a series of systematic reviews on mental health and policing
CPIT III – An RCT to determine the effectiveness of providing financial incentives to pregnant smokers to encourage smoking cessation
IMPACT – Increasing physical activity in a medium secure service: the development and feasibility of a physical activity intervention
PROTECT - Preventing blood borne virus infection in people who inject drugs in the UK: intervention development and feasibility study
REEACT – The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy for people with depression
RESPECT – Randomised Evaluation Sexual Health Promotion Evidence for Care and Treatment: a feasibility study of an intervention to promote sexual health for people with serious mental illness
SCIMITAR - Smoking Cessation Intervention for severe Mental Ill Health Trial (SCIMITAR): a pilot randomised control trial
SCIMITAR+ – An RCT evaluating the effectiveness of “bespoke smoking cessation” intervention for people with severe mental ill health
Y-SBNT – Family and social network intervention for young people who misuse alcohol and drugs: a feasibility randomised controlled trial
Musculoskeletal
ATLAS - A trial evaluating Alexander Technique and acupuncture for chronic neck pain.
CaTS – a retrospective cohort study to identify current demographics and treatment pathways for calcific tendinitis
HERO – Hydroxychloroquine Effectiveness in Reducing symptoms of hand Osteoarthritis: an RCT
OKIS – Orthotic management of instability of the knee in neuromuscular disease: systematic review, qualitative study, survey and costing analysis
OPAL – A feasibility study of Occupational advice for Patients undergoing Arthroplasty of the Lower limb to improve speed of recovery
OSTRICH – An RCT of the effectiveness of two types of orthotics for treatment of symptomatic flat feet in children
OTIS – An RCT examining the effectiveness of Occupational Therapist led home environmental assessment and modification for the reduction of falls among high-risk older people
PROMOTE – Placebo-controlled trial of methotrexate to treat painful knee osteoarthritis
REFORM – Improving balance to prevent falls in older people: an RCT
SCOOP – SCreening for Osteoporosis in Older women for the Prevention of fractures: an RCT
SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers
STEPFORWARD – Patient acceptability of a novel prosthetic device: a randomised feasibility study in older patients with vascular-related amputations and multi-morbidities
YACBAC - The York acupuncture for back pain trial.
Oral Health
BRIGHT – Brushing RemInder 4 Good oral HealTh: an RCT of a school and text-based programme to improve the oral health of young people living in deprived areas
Pharmaceutical
BreatheMOR-HF – An RCT to determine whether prescribing slow-release daily morphine tablets to individuals with heart failure helps with breathlessness
HERO – Hydroxychloroquine Effectiveness in Reducing symptoms of hand Osteoarthritis: an RCT
LEISH Sudan – A Phase IIa/IIb clinical trial to evaluate the therapeutic efficacy of ChAd63-KH vaccine in patients with persistent post kala-azar dermal leishmaniasis
PROMOTE – Placebo-controlled trial of methotrexate to treat painful knee osteoarthritis
RETREAT (F) - A feasibility study for an RCT of treatment withdrawal in psoriatic arthritis
Sleep disturbance – Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbances in children with neurodevelopmental disorders: a systematic review
Primary care and community
ACE To Hear – A feasibility trial of delivering the Active Communication Education programme to unsuccessful new hearing-aid users
ACIBS - A trial to establish the effectiveness and cost-effectiveness of acupuncture in primary care for irritable bowel syndrome.
BRIGHT – Brushing RemInder 4 Good oral HealTh: an RCT of a school and text-based programme to improve the oral health of young people living in deprived areas
CASPER – An RCT examining the effectiveness of Collaborative Care in Screen-Positive EldeRs
EVerT2 – An RCT of needling vs. nonsurgical debridement for the treatment of a Verruca
FIREFLI – An RCT to establish the effectiveness of safe and well visits by the Fire and Rescue Service in preventing falls and improving quality of life for people aged 70+
GYY – An RCT assessing the effectiveness of Gentle Years Yoga for older adults with multimorbidity, for improving health-related quality of life
HOT – An RCT of home oxygen therapy for patients with chronic heart failure
IMPACT-C19-P – The impact of Covid-19 on the delivery and receipt of prison healthcare in England: a mixed methods study
PACT – a programme of six inter-linked studies to understand and improve the experience and safety of care for elderly patients during transitions from hospital to home
REEACT – The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy for people with depression
Sleep disturbance – Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbances in children with neurodevelopmental disorders: a systematic review
Public health and prevention
EXACT – EXercise for Adults with Crohn's disease: a feasibility Trial
FIREFLI – An RCT to establish the effectiveness of safe and well visits by the Fire and Rescue Service in preventing falls and improving quality of life for people aged 70+
Gateway – An RCT examining the effectiveness of an out-of-court community-based intervention aimed at improving health and well-being for young adult offenders
GYY – An RCT assessing the effectiveness of Gentle Years Yoga for older adults with multimorbidity, for improving health-related quality of life
IMPACT-C19-P – The impact of Covid-19 on the delivery and receipt of prison healthcare in England: a mixed methods study
MCLASS – Muslim Communities Learning About Second-hand Smoke in Bangladesh: a pilot study
MCLASS II – Muslim Communities Learning About Second-hand Smoke in Bangladesh: an effectiveness-implementation hybrid study
MiQuit 3 – An RCT and meta-analysis testing effectiveness and cost-effectiveness of a tailored text message programme for smoking cessation in pregnancy
OTIS – An RCT examining the effectiveness of Occupational Therapist led home environmental assessment and modification for the reduction of falls among high-risk older people
PACT - A programme of six inter-linked studies to understand and improve the experience and safety of care for elderly patients during transitions from hospital to home
Patient Involvement in Patient Safety – A programme to design, develop and evaluate approaches to engage patients to protect against unintended harm
PERSONAL-EYE-S – Assessing the possibility of conducting a full scale RCT into the effectiveness of digitally printed versus hand-painted artificial eyes in adults: a feasibility study
PIP – an evaluation of a programme designed to increase physical activity in pre-schoolers in the playground
Project Teensleep – a pilot study of the impact of sleep education on students’ sleep
REFORM – Improving balance to prevent falls in older people: an RCT
RESPECT – A feasibility Randomised Evaluation Sexual Health Promotion Evidence for Care and Treatment, an intervention to promote sexual health for people with serious mental illness
SCOOP – Screening for osteoporosis in older women for the prevention of fractures: an RCT
SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers
UNITING – A multi-phase study to Understand the uptake of Immunisations in Traveller and Gypsy communities and inform interventions to promote uptake
Respiratory
BreatheMOR-HF – An RCT to determine whether prescribing slow-release daily morphine tablets to individuals with heart failure helps with breathlessness
DOC – An RCT to Determine the Optimal approach to identifying individuals with Chronic obstructive pulmonary disease
Screening
DOC – An RCT to Determine the Optimal approach to identifying individuals with Chronic obstructive pulmonary disease
EMPRESS – A study comparing the pathway to diagnosis as an emergency presentation compared to diagnosis via the 2WW pathway for lung and colorectal cancer
SCOOP – Screening for osteoporosis in older women for the prevention of fractures: a randomised controlled trial
STRATEGIC – An RCT of interventions to increase cervical screening uptake at first invitation in young women
Surgery and devices
CaTS – a retrospective cohort study to identify current demographics and treatment pathways for calcific tendinitis
EVerT2 – An RCT of needling vs. nonsurgical debridement for the treatment of a Verruca
FARSTER – A mixed methods feasibility study of early outpatient review and early cardiac rehabilitation after coronary artery bypass grafting
KReBs – A RCT of the effect of a Two-layer Compression Bandage System on Knee Function following Total Knee Arthroplasty
L1FE – A RCT investigating the effectiveness of surgical fixation with INFIX compared to non-surgical management of LC-1 fragility fractures in older adults
PERSONAL-EYE-S – A feasibility study of digitally printed versus hand-painted artificial eyes in adults
Profher – An RCT to evaluate the effectiveness of surgical versus non-surgical treatment for the majority of displaced fractures of the proximal humerus in adults
OKIS – Orthotic management of instability of the knee in neuromuscular disease: systematic review, qualitative study, survey and costing analysis
OPAL – A feasibility study of Occupational advice for Patients undergoing Arthroplasty of the Lower limb to improve speed of recovery
OSTRICH – An RCT of the effectiveness of two types of orthotics for treatment of symptomatic flat feet in children
QIST – Avoiding surgical site infection and anaemia at the time of surgery using a quality improvement Collaborative model: an RCT
SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers
STEPFORWARD – Patient acceptability of a novel prosthetic device: a randomised feasibility study in older patients with vascular-related amputations and multi-morbidities
SWIFFT – An RCT to determine whether adults with a fracture of the scaphoid waist should receive plaster cast treatment or surgical fixation
UK FROST – A RCT comparing three treatments for patients referred to secondary care with a frozen shoulder
Wounds
AVURT – An RCT assessing the effectiveness of aspirin for the treatment of venous leg ulcers
KReBs – An RCT of the effect of a Two-layer Compression Bandage System on Knee Function following Total Knee Arthroplasty
Open surgical wounds – Describing the problem and identifying effective treatments
VenUS IV – An RCT to compare the clinical and cost effectiveness of compression hosiery compared with 4-layer compression bandaging in terms of ulcer healing and quality of life
