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The clinical and cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations

A pragmatic, multi-centre, open label, randomised, normal care-controlled, clinical trial with two parallel treatment arms of equal size. Participants randomised to one of two self-management plans using a computer-based randomisation system (Nottingham Clinical Trials Unit) stratified by centre, smoking status, and maintenance inhaled corticosteroid dose. Participants will follow the plan for 12 months from randomisation. York will be undertaking the cost-effectiveness analysis.