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CADET: Multi-Centre randomised controlled trial of collaborative care for depression

'Collaborative care' is a systems-level intervention to improve the treatment of depression in primary care. It has a strong American evidence base but there are no definitive UK trials. Having developed and pilot tested a UK collaborative care protocol using the MRC's complex interventions framework, the research team will now conduct a large scale definitive RCT to determine the clinical and cost-effectiveness of this intervention in the management of moderate to severe depression. This will be a two-arm trial, with usual GP care as the control arm. We will recruit 550 participants and the primary outcomes are severity of depression at 4 and 12 months follow-up. We will also carry out a qualitiative process evaluation, as well as an economic analysis.

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