Laura Wiley
Research Fellow (Trial Coordinator)

Profile

Biography

Laura has a background in biological ageing research and clinical cancer research.

Laura completed her PhD in Biology of Ageing at Newcastle University in 2014. Laura’s research aimed to assess candidate biomarkers of ageing for their reliability and validity it terms of their association with age-related outcomes. During her PhD she became particularly interested in data quality assurance.

Between 2015-2018, Laura worked on various urological cancer randomised clinical trials within the Clinical Trials and Statistics Unit at the Institute of Cancer Research, London. Her roles included trial coordination, data management and trial monitoring. The trials she worked on were a mixture of paper based and electronic data collection. Laura was involved in the design, use and maintenance of clinical research databases and also quality assurance procedures to ensure data was of high accuracy and reliable. Laura also ensured trial recruitment and retention were monitored and contributed to procedures for dealing with any potential issues in accrual.

Laura joined the York Trials Unit as a Research Fellow in December 2018. She is currently the lead trial coordinator for The Gentle Years Yoga (GYY) Trial, an individually randomised controlled, two arm, pragmatic, multi-centre trial to determine the clinical and cost-effectiveness of an adapted yoga programme for older adults with multimorbidity.

Qualifications

• PhD in Biology of Ageing (2014)
• MRes in Medical and Molecular Bioscience (2009)
• BSc (Hons) in Human Biology (2007)

Research

Overview

Laura has research interests in the following areas:

• Lifestyle determinants of health and ageing
• Interventions to maintain and improve healthy ageing and wellbeing
• Data quality assurance 
• Recruitment and retention of trial participants

Projects

• Gentle Years Yoga (GYY) - Individually randomised controlled, two arm, pragmatic, multi-centre trial to determine the clinical and cost-effectiveness of an adapted yoga programme for older adults with multimorbidity

Research group(s)

• Trials and Statistics

Publications

Full publications list

• Laura Wiley's publications

Abstracts

• 111: A single-arm trial evaluating one cycle of BEP as adjuvant chemotherapy in high-risk, stage 1 non-seminomatous or combined germ cell tumors of the testis (NSGCTT) (Journal of Clinical Oncology, 2017) Huddart, R. A., Joffe, J. K., White, J. D., Hutton, P., Lewis, R., Mazhar, D., Osborne, C., Piercy, D., Wiley, L., Witts, S., Maynard, L., Hall, E., Cullen, M. H., 111 Trial Management Group.
• Recruitment aids for a phase II randomised trial in low risk bladder cancer (Trials, 2018) Penegar, S., Lewis, R., Catto, J., Cresswell, J., Griffiths, L., Hill, M., Kelly, J., Knight, A., McGrath, J., Wiley, L.
• Results of CALIBER: A phase II randomised feasibility trial of chemoablation versus surgical management in low risk non-muscle invasive bladder cancer (European Urology Supplements, 2018) Mostafid, H., Cresswell, J., Griffiths, L., Kelly, J., Knight, A., Catto, J., Davenport, K., Feber, A., Knowles, M., McGrath, J., Cooke, P., Masood, S., Goubar, A., Penegar, S., Porta, N., Wiley, L., Lewis, R., Hall, E.
• Results of CALIBER: A phase II randomised feasibility trial of chemoablation with MMC versus surgical management in low risk non-muscle invasive bladder cancer (NMIBC) (British Journal of Cancer, 2018) Mostafid, H., Cresswell, J., Griffiths, L., Kelly, J., Knight, A., Catto, J., Davenport, K., Feber, A., Knowles, M., McGrath, J., Cooke, P., Masood, S., Goubar, A., Penegar, S., Porta, N., Wiley, L., Lewis, R., Hall, E.
• PD66-04 RESULTS OF CALIBER: a phase II randomised feasibility trial of chemoablation versus surgical management in low risk non-muscle invasive bladder cancer (NMIBC) (The Journal of Urology, 2018) Mostafid, H., Cresswell, J., Griffiths, L., Kelly, J., Knight, A., Catto, J., Davenport, K., Feber, A., Knowles, M., McGrath, J., Cooke, P., Masood, S., Goubar, A., Penegar, S., Porta, N., Wiley, L., Lewis, R., Hall, E.
• Radiology review of MRI screening used to detect rSCC (radiological spinal cord/compression) in a randomised trial of asymptomatic castrate resistant prostate cancer patients with spinal metastasis (British Journal of Cancer, 2018) Sohaib, A., Tomkinson, K., Rich, P., Houston, G., Cruickshank, C., Griffin, C., Hassan, S., Wiley, L., Gibbs, S., Henry, A., Horan, G., Payne, H., Pedley, I., Srihari, N. N., Hall, E., Dearnaley, D.
• 12 month results of CALIBER: A phase II randomised feasibility trial of chemoablation with MMC versus surgical management in low risk (LR) non-muscle invasive bladder cancer (NMIBC) (European Urology Supplements, 2019) Mostafid, H., Cresswell, J., Griffiths, L., Kelly, J., Knight, A., Catto, J., Davenport, K., Feber, A., Knowles, M., McGrath, J., Cooke, P., Masood, S., Goubar, A., Penegar, S., Porta, N., Wiley, L., Lewis, R., Hall, E.
• Methodological review of evidence of risk of bias in cluster randomised trials (Trials, 2019) Torgerson, D., Clark, L., Cockayne, S., Hirst, C., Howe, L., Roche, J., Turner, E., Wiley, L.