Methodological development underpins all of CRD research. We have particular interests in developing and applying methods for synthesis of individual participant data, enhancement of statistical models, survival analysis, predicting risk and future health outcomes, and combining observational with experimental data. We are involved in developing approaches to utilise trial data and information increasingly being released under open data and data sharing initiatives. Other areas of interest include network meta-analysis, developing statistical approaches to determine when to update a systematic review, methods of narrative synthesis and defining methods and approaches to “rapid evidence synthesis”.