Dr Alyssa-Jennifer Avestro

Research

Research

Multi-Dimensionally Conjugated Supra(Macro)Molecular Materials

The overarching aim of Avestro Group research is to understand how precise π-electronic interactions between functional aromatic surfaces can give rise to a material’s inherent and emergent optical, electronic and transmission properties. We target organic synthetic molecules and (supra-)macromolecular materials that present fundamentally interesting through-space π-electronic geometries arranged in one, two and even three dimensions of space. Our strategies involve supramolecular self-assembly, coordination chemistry, as well as precisely orientated covalent bonding into shape-persistent structures. In all projects, Avestro Group researchers exploit an interdisciplinary array of methods including organic synthesis, advanced spectroscopy, electrochemistry, diffraction, materials analysis, and computational modelling to study our systems. Promising materials will be pursued further for semiconductor, energy storage (e.g., rechargeable organic batteries) and energy conversion (e.g., organic photovoltaics, OLEDs) applications. Substrates, electrodes and prototypical devices are prepared in-house and alongside collaborators in Malaysia, China, and India (i.e., aligned with the Global Challenges Research Fund remit) to enhance the excellence and impact of our research.

Who Supports A-Team Research?

Avestro Group research is currently supported by generous financial contributions from The Royal Society, the UKRI’s Global Challenges Research Fund, the Engineering and Physical Sciences Research Council (EPSRC), the Laidlaw Foundation, Universities UK International (UUKi) and the Departments of Chemistry at the University of York and Durham University. We are also grateful for the support provided to us in the past by the Royal Commission for the Exhibition of 1851, the Durham Greenspace Initiative, and the Royal Society of Chemistry. 

Learn more (below) about Avestro Group sponsors, both past and present:

• The Royal Society
• Global Challenges Research Fund
• Engineering and Physical Sciences Research Council
• Royal Commision Exhibition of 1851
• Universities UK International
• Durham University: Durham Energy Institute
• Royal Society of Chemistry
• Laidlaw Scholars: Undergraduate Research and Leadership Programme
• Durham University: Greenspace 

Publications

Publications 

Independent Work (Post-PhD)

Saidi, N. M.; Numan, A.; Omar, F. S.; Apperley, D. C.; Algaradah, M. M.; Ramesh, K.; Avestro, A.-J.*; Subramaniam, R. T.* “Sonochemically-Enhanced Polymer Gel Electrolytes for High Ion Mobility in Dye-Sensitised Solar Cells,” ACS App. Mater. Inter. 2018, under review.

Sturala, J.; Etherington, M. K.; Bismillah, A. N.; Higginbotham, H. F.; Aguilar, J. A.; Bromley, E. H. C.; Avestro, A.-J.*; Monkman, A. P.*; McGonigal, P. R.* “Excited-State Aromatic Interactions in the Aggregation-Induced Emission of Molecular Rotors,” J. Am. Chem. Soc. 2017, 139, 17882–17889.

Avestro, A.-J.* “Catalysing Excellence: In a Competitive High-Stakes Arena, Can We Be Our Own Catalysts for Success?” Chem 2016, 1, 13–15.

Mentored Work

Liu, L.; Cotelle, Y.; Avestro, A.-J.; Sakai, N.; Matile, S.* “Asymmetric Anion–π Catalysis of Iminium / Nitroaldol Cascades to Form Cyclohexane Rings with Five Stereogenic Centers Directly on π-Acidic Surfaces,” J. Am. Chem. Soc., 2016, 138, 7876–7879.

Cotelle, Y.; Benz, S.; Avestro, A.-J.; Ward, T. R.; Sakai, N.; Matile, S.* “Anion–π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces,” Angew. Chem. Int. Ed. 2016, 55, 4275–4279.

Zhao, Y.; Cotelle, Y.; Avestro, A.-J.; Sakai, N.; Matile, S. “Asymmetric Anion–π Catalysis: Enamine Addition to Nitroolefins on π-Acidic Surfaces,” J. Am. Chem. Soc. 2015, 137, 11582–11585.

McGonigal, P. R.; Deria, P.; Hod, I.; Moghadam, P. Z.; Avestro, A.-J.; Horwitz, N. E.; Gibbs-Hall, I. C.; Blackburn, A. K.; Chen, D.; Botros, Y. Y.; Wasielewski, M. R.; Snurr, R. Q.; Hupp, J. T.; Farha, O. K.; Stoddart, J. F.* "Electrochemically Addressable Trisradical Rotaxanes Organized Within a Metal-Organic Framework," Proc. Natl. Acad. Sci. USA, 2015, 112, 11161–11168.
 - Invited contribution to the issue of Inaugural Articles by 2014-elected members of the National Academy of Sciences

Chen, D.†; Avestro, A.-J.†; Chen, Z.; Sun, J.; Wang, S.; Xiao, M.; Erno, Z.; Algaradah, M. M.; Amine, K.; Nassar, M. S.; Meng, Y.; Stoddart, J. F. "A Rigid Naphthalenediimide Triangle for Organic Rechargeable Lithium-ion Batteries," Adv. Mater. 2015, 27, 2907–2912. [†Equal Contributions]
 - Featured on the cover of Volume 27, Issue 18 

Wilson, E. A.; Vermeulen, N. A.; McGonigal, P.R.; Avestro, A.-J.; Stoddart, J. F.* “A Dynamic Scrambling Methodology for Preparing a Mixed-Ring Hetero[3]rotaxane,” Chem. Commun. 2014, 50, 9665–9668.

Juríček, M.; Barnes, J. C.; Strutt, N. L.; Vermeulen, N. A.; Ghooray, K. C.; Dale, E. J.; McGonigal, P. R.; Blackburn, A. K.; Avestro, A.-J.; Stoddart, J. F.* “An ExBox [2]Catenane,” Chem. Sci. 2014, 5, 2724–2731.

Avestro, A.-J.; Gardner, D. M.; Vermeulen, N. A.; Wilson, E. A.; Schneebeli, S. T.; Whalley, A. C.; Belowich, M. E.; Carmieli, R.; Wasielewski, M. R.; Stoddart, J. F.* “Gated Electron Sharing Within Naphthalene Diimide-based Oligorotaxanes,” Angew. Chem. Int. Ed. 2014, 53, 4442–4449; Angew. Chem., 2014, 126, 4531–4538.

Usta, H.†*; Yilmaz, M. D.; Avestro, A.-J.; Boudinet, D.; Denti, M.; Zhao, W.; Stoddart, J. F.*; Facchetti, A.* “BODIPY–Thiophene Copolymers as p-Channel Semiconductors for Organic Thin-Film Transistors,” Adv. Mater. 2013, 25, 4327–4334. [†Principal Investigator]

Fahrenbach, A. C.; Warren, S. C.; Incorvati, J. T.; Avestro, A.-J.; Barnes, J. C.; Stoddart, J. F.*; Grzybowski, B. A.* “Organic Switches for Surfaces and Devices,” Adv. Mater. 2012, 3, 331–348.

Basuray, A. N.; Jacqout de Rouville, H.-P.; Hartlieb, K. J.; Kikuchi, T.; Strutt, N. L.; Bruns, C. J.; Ambrogio, M. W.; Avestro, A.-J.; Schneebeli, S. T.; Fahrenbach, A. C.; Stoddart, J. F.* “The Chameleonic Nature of Diazapero-pyrenium Recognition Processes,” Angew. Chem. Int. Ed. 2012, 51, 11872–11877; Angew. Chem. 2012, 124, 12042–12047.

Avestro, A.-J.; Belowich, M. E.; Stoddart, J. F.* “Cooperative Self-Assembly: Producing Synthetic Polymers with Precise and Concise Primary Structures,” Chem. Soc. Rev. 2012, 41, 5881–5895.
 - Invited contribution to Special Issue on Supramolecular Polymers
 - Featured on the cover of Volume 41, Issue 18

Rodionov, V. O.; Gao, H.; Scroggins, S. T.; Unruh, D. A.; Avestro, A.-J.; Fréchet, J. M. J.* “Easy Access to a Family of Polymer Catalysts from Modular Star Polymers,” J. Am. Chem. Soc. 2010, 132, 2570–2572.
 - Article featuring undergraduate research

Intellectual Property

Chen, D.; Avestro, A.-J.; Sun, J.; Erno, Z. “Rigid Naphthalenediimide Triangle Structures.” Patent Application WO2016149611 A1 and US20160276669 A1: Filed 18 Mar 2016,† Published 22 Sept 2016 (†Priority Filing Date: Invention claims priority to US Provisional Patent 62/135,339: Filed 19 Mar 2015)

Ratto, T. V.; Holt, J. K.; Szmodis, A.; Avestro, A.-J.; O’Connell. “Non-Reactive Process for Fixing Nanotubes in a Membrane in Through-Passage Orientation.” US Patent US9095821 B1: Filed 09 Aug 2011, Granted 04 Aug 2015

Vacancies

Vacancies

The Avestro Group welcomes applications from all career levels: (a) PhD, (b) postdoctoral, (c) final-year Master’s, (d) non-final year undergraduates, and (e) visiting researchers/Erasmus+ students. Successful applicants will join a diverse and multi-disciplinary research group in the Chemistry Department at York and can expect regular engagement with members of the original A-Team based at Durham University and our collaborators from international partners. All projects in the Avestro Group involve organic synthesis and thus, applicants should be experienced / keen to undertake such activities. Researchers are also expected to hone their skills in at least one additional experimental or analytical technique (see Key Activities) to support peer-collaborative work within the group.

Please contact Alyssa directly (alyssa-jennifer.avestro@york.ac.uk) for details on project openings and communicating expressions of interest. Please include a CV, a summary of your experience, and copies of any relevant publications. Undergraduates and visiting students should note that a 10-week minimum research stay is typically necessary to complete training and make meaningful progress on projects.

We especially encourage self-funded researchers and those interested in applying for fellowships to get in touch. A non-exhaustive list of funding opportunities is included below and will be updated regularly. Please contact Alyssa at least two months in advance of any funding deadline to discuss your eligibility, fit and to develop proposals.

Undergraduate / Master’s / Short Term Projects

Activities in support of primary research projects

• Microwave-assisted synthesis of functional rylenes and exotic aromatic imides
• Light-emitting aromatic imides for bright OLED investigations
• High-resolution microscopy of H-bonded assemblies
• Crystal engineering of redox-active molecules and coordination materials
• Building a better battery: rechargeable organic energy storage devices
• Controlled assembly and properties of shape-persistent 'molecular clips'