Wendy Offen

01904 328278
Email: wendy.offen@york.ac.uk

Research Technician

Wendy Offen works in the group of Professor Gideon Davies, FRS. Her main interests are in the structural enzymology of diverse carbohydrate-active enzymes and biocatalysts. Wendy works on the O-GlcNAc modification, and related hexosaminidase enzymes, and on industrially-relevant amylases, cellulases and xyloglucanases. She is interested in enzymes with applications in lignocellulosic biomass degradation such as LPMOs and xylan esterases. She also has a long standing interest in mannosidase catalysis, and studies interactions of glycoside hydrolases with activity-based probes.

Selected Recent Publications

Synthesis of broad-specificity activity-based probes for exo-β-mannosidases McGregor et al., Org Biomol Chem, 2022, 20, 877-886
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents Rowland et al., Chem Eur J, 2021, 27, 16377-16388
Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on α-1,6 Mannanases Schröder et al., Chem Eur J, 2021, 27, 9519-9523
Discovery of a Fungal Copper Radical Oxidase with High Catalytic Efficiency toward 5-Hydroxymethylfurfural and Benzyl Alcohols for Bioprocessing Mathieu et al., ACS Catal. 2020, 10, 5, 3042-3058
Gluco-1H-imidazole; a new class of azole-type β-glucosidase inhibitor Schröder et al., J Am Chem Soc, 2018, 140, 5045-5048.
Structural and functional insight into human O-GlcNAcase Roth et al., Nature Chem Biol, 2017, 13, 610–612