Dr Nicholas Yates

Postdoctoral Research Associate

Nick is a Postdoctoral Research Associate working with Dr Martin Fascione and Dr Nathalie Signoret, working in both the Department of Chemistry and the York Structural Biology Laboratory. He completed his DPhil in Biological Chemistry at the University of York in 2021. Nick previously worked on the development of bio-orthogonal crosslinking chemistries to facilitate the electroactive immobilisation of redox proteins/enzymes onto electrode surfaces, and on the development of computational tools to facilitate the electrochemical interrogation of electroactively-immobilised redox species, working under the supervision of Dr Alison Parkin and Dr Martin Fascione.

Research Interests

Nick’s current project is focused on the development of novel immunotherapy treatments, involving the usage of bio-orthogonal ligation to conjugate genetic payloads to nanobodies selective for an antigen over-expressed on many cancer cells.

Selected Publications

Yates, N. D. et al. Aldehyde-Mediated Protein-to-Surface Tethering via Controlled Diazonium Electrode Functionalization Using Protected Hydroxylamines. Langmuir 36, 5654-5664, doi: https://doi.org/10.1021/acs.langmuir.9b01254 (2020).
Yates, N. D. J., Fascione, M. A. & Parkin, A. Methodologies for “Wiring” Redox Proteins/Enzymes to Electrode Surfaces. Chemistry – A European Journal 24, 12164-12182, doi: https://doi.org/10.1002/chem.201800750 (2018).
Lloyd-Laney, H. O. et al. Using Purely Sinusoidal Voltammetry for Rapid Inference of Surface-Confined Electrochemical Reaction Parameters. Analytical Chemistry 93, 2062-2071, doi: https://doi.org/10.1021/acs.analchem.0c03774 (2021).
Yates, N. D. J. et al. Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus. Journal of Chemical Education 96, 1245-1249, doi: https://doi.org/10.1021/acs.jchemed.8b00787 (2019).