Morwan Osman

Tel: (+44) (0)1904 32 4520
Email: mmo512@york.ac.uk

Research Associate in Mycobacterial Structural Biology

Morwan is a Postdoctoral Research Associate working with Dr. Jamie Blaza, at the York Structural Biology Laboratory. They completed their PhD in Molecular & Cellular Biology from the University of Washington in 2018. Previously, Morwan worked on the role of the Mycobacterium tuberculosis ESX-1 secretion system in evading host defences, under the supervision of Professor Lalita Ramakrishan, FRS, FMedSci at the University of Washington and the University of Cambridge.

Research Interests

Morwan’s research interests focus on Mycobacterium tuberculosis, the causative agent of the disease tuberculosis. Their current work combines microbiological, biophysical, and structural methods to probe the interaction between antibiotics and the oxidative phosphorylation systems of M. tuberculosis.

Selected Publications

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence.
MM Osman, JK Shanahan, et al. Proceedings of the National Academy of Sciences, 2022.
DOI: 10.1073/pnas.2122161119

Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage.
MM Osman, AJ Pagán, JK Shanahan, L Ramakrishnan. PLoS ONE, 2020.
DOI: 10.1371/journal.pone.0233252

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions
WH Conrad, MM Osman, et al. Proceedings of the National Academy of Sciences, 2017.
DOI: 10.1073/pnas.1620133114