Isabelle Pickles

Postdoctoral Research Associate

Isabelle is a postdoctoral research associate in the lab of Professor Gideon Davies at the York Structural Biology Laboratory. She uses activity-based chemical probes to investigate carbohydrate-degrading enzymes. Isabelle moved to the University of York after completing a PhD at the University of Leeds under the supervision of Dr Robin Bon, with co-supervision from Dr Stephen Muench, Dr Megan Wright and Dr Stuart Warriner. At Leeds, she designed and developed chemical tools to study TRPC1/4/5 ion channels and their roles in human health and disease. In 2017, Isabelle graduated from Durham University with a MChem in Chemistry, undertaking Master’s project work with Professor AnnMarie O’Donoghue.

Selected Publications

Claudia C. Bauer,^‡ Aisling Minard,^‡ Isabelle B. Pickles,^‡ Katie J. Simmons, Eulashini Chuntharpursat-Bon, Matthew P. Burnham, Nikil Kapur, David J. Beech, Stephen P. Muench, Megan H. Wright, Stuart L. Warriner and Robin S. Bon, Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels, RSC Chemical Biology, 2020, 1, 436-448. (^‡ these authors contributed equally).
Alireza Baradaran-Heravi,^‡Claudia C. Bauer,^‡Isabelle B. Pickles, Sara Hosseini-Farahabadi, Aruna D. Balgi, Kunho Choi, Deborah M. Linley, David J. Beech, Michel Roberge, Robin S. Bon, Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903, Journal of Biological Chemistry, 2022, 298, 101546.
Aisling Minard, Claudia C. Bauer, Eulashini Chuntharpursat-Bon, Isabelle B. Pickles, David J. Wright, Melanie J. Ludlow, Matthew P. Burnham, Stuart L. Warriner, David J. Beech, Katsuhiko Muraki, Robin S. Bon, Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative, British Journal of Pharmacology, 2019, 176, 3924-3938.
Sophie J.Hesketh, David P.Klebl, Anna J.Higgins, MarenThomsen, Isabelle B.Pickles, FrankSobott, AsipuSivaprasadarao, Vincent L.G.Postis, Stephen P.Muench, Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation, Biochimica et Biophysica Acta (BBA) – Biomembranes, 2020, 1862, 183192.