Department of Chemistry
Group Publications:
2020
2020
- Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade.
J A Rossi-Ashton, A K Clarke, R J K Taylor, W P Unsworth, Org. Lett., 2020, 3, 1175-1181. - Visible-Light-Induced Intramolecular Charge Transfer in the Radical Spirocyclisation of Indole-Tethered Ynones.
H E Ho, A Pagano, J A Rossi-Ashton, J R Donald, R G Epton, J C Churchill, M J James, P O’Brien, R J K Taylor, W. P. Unsworth, Chem. Sci., 2020, 11, 1353-1360.
2019 to 2010
2019 2018 2017 2016 2015 2014 2013 2012 2011 2010
2019
- Merging π-Acid and Pd Catalysis: Dearomatising Spirocyclisation/ Cross Coupling Cascade Reactions of Alkyne-Tethered Aromatics.
H E Ho, M J James, T C Stephens, T C Payne, P O’Brien, R J K Taylor, W P Unsworth, ACS Catalysis, 2019, 9, 504-510. - Indole Synthesis Using Silver Catalysis.
A K Clarke, H E Ho, J A Rossi-Ashton, R J K Taylor, W P Unsworth, Chem. - Asian J., 2019, 14, 1900 –1911. - Synthetic and Mechanistic Studies into the Rearrangement of Spirocyclic Indolenines into Quinolones.
R G Epton, A K Clarke, R J K Taylor, J M Lynam, W P Unsworth, Eur. J. Org. Chem., 2019, 5563–5571. - A Marine Viral Halogenase that Iodinates Diverse Substrates.
D S Gkotsi, H Ludewig, S V Sharma, J Connolly, J Dhaliwal Y Wang, W P Unsworth, R J K Taylor, M M W McLachlan, S Shanahan, J H Naismith, R J M Goss, Nature Chemistry, 2019, 11, 1091-1097. - A Copper(II)-Mediated Radical Cross-Dehydrogenative Coupling/Sulfinic acid Elimination Approach to 2-Quinolones.
R M Gorman, T E Hurst, W F Petersen, R. J. K. Taylor, Tetrahedron, 2019, 75, 130711.
2018
- Ag(I)-Catalysed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-tethered Ynones: Total Synthesis of Indolizidine 209D.
H E Ho, M J James, P O’Brien, R J K Taylor, W P Unsworth, Org Lett., 2018, 20, 1439-1443. - Dearomatising Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides.
J T R Liddon, J A Rossi-Ashton, R J K Taylor, W P Unsworth, Org. Lett., 2018, 20, 3349-3353. - Divergent Reactivity of Phenol- and Anisole-Tethered Donor-Acceptor α-Diazoketones.
A K Clarke, W P Unsworth, R J K Taylor, Tetrahedron, 2018, 74, 5374-5382.
Invited article (Barton Special Issue) - "Back-to-Front" Indole Synthesis using Silver(I) Catalysis: Unexpected C-3 Pyrrole Activation Mode Supported by DFT.
A K Clarke, J M Lynam, R J K Taylor, W P Unsworth, ACS Catalysis, 2018, 8, 6844-6850. - Application of Copper(II)-Mediated Radical Cross-Dehydrogenative Coupling to Prepare Spirocyclic Oxindoles and to a Formal Total Synthesis of Satavaptan.
T E Hurst, R Gorman, P Drouhin, R J K Taylor, Tetrahedron, 2018, 74, 6485-6496.
Invited article (Ghosez Special Issue) - Divergent Reactivity of Indole-Tethered Ynones with Ag(I) and Au(I) Catalysts: A Combined Synthetic and Computational Study.
J T R Liddon, J A Rossi-Ashton, A K Clarke, J M Lynam, R J K Taylor, W P Unsworth, Synthesis, 2018, 50, 4829-4836.
2017
- Dearomatisation Approaches to Spirocyclic Dienones via the Electrophilic Activation of Alkynes.
A K Clarke, J T R Liddon, J D Cuthbertson, R J K Taylor, W P Unsworth, Org. Biomol. Chem., 2017, 15, 233-245. - A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.
T E Hurst, R J K Taylor, Eur. J. Org. Chem., 2017, 203-207. - Photoredox-catalyzed reductive carbamoyl radical generation: A redox-neutral intermolecular addition–cyclization approach to functionalized 3,4-dihydroquinolin-2-ones.
W F Petersen, R J K Taylor, J R Donald, Org. Lett., 2017, 19, 874-877. - Photoredox-Catalyzed Procedure for Carbamoyl Radical Generation: 3,4-Dihydroquinolin-2-one and Quinolin-2-one Synthesis.
W F Petersen, R J K Taylor, J R Donald, Org. Biomol. Chem., 2017, 15, 5831-5845. - A Low-Temperature, Transition Metal-Free Cross Dehydrogenative Coupling Protocol for the Synthesis of 3,3-Disubstituted Oxindoles.
J R Donald, R J K Taylor, W F Petersen, J. Org. Chem., 2017, 82, 11288−11294. - Selective Synthesis of Three Product Classes from Imine and Carboxylic acid Precursors via Direct Imine Acylation.
J A Rossi-Ashton, R J K Taylor, W P Unsworth, Org. Biomol. Chem., 2017, 15, 7527-7532.
2016
- Organometallic Routes to Novel Steroids Containing Heterocyclic C-17 Side-Chains.
L Vitellozzi, G D McAllister, T Genski, R J K Taylor, Synthesis 2016, 48, 48. - A selective C–H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products.
M G Lloyd, M D'Acunto, R J K Taylor, W P Unsworth, Org. Biomol. Chem., 2016, Advance Article - Synthetic Studies Towards the Africanane Sesquiterpenes via the Cope Rearrangement of gem-Dimethyl Substituted Divinyl Cyclopropanes.
J D Osler, W P Unsworth, R J K Taylor, Synlett 2016, 27, 70-74.
Invited article (Steve Ley Special Issue) - Synthesis of Spirocyclic Indolenines (Invited Review).
M J James, W P Unsworth, P O’Brien, R J K Taylor, Chem. Eur. J. 2016, 22, 2856-2881. - From Heteroaromatic acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis.
S J Chambers, G Coulthard, W P Unsworth, P O’Brien, R J K Taylor, Chem. Eur. J., 2019, 22, 6496-6500. - Direct Imine Acylation: a Versatile Method for the Synthesis of Nitrogen Containing Heterocycles, Spirocycles and Natural Products.
W P Unsworth, R J K Taylor, Synlett, 2016, 27, 2051-2064. - Catalyst Driven Scaffold Diversity: Divergent Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones.
J T R Liddon, M J James, A K Clarke, P O’Brien, R J K Taylor, W P Unsworth, Chem. Eur. J., 2016, 22, 8777-8780. - Synthetic Approaches to Pallimamine and Analogues using Direct Imine Acylation.
T O Ronson, C Kitsiou, R J K Taylor, W P Unsworth, Tetrahedron, 2016, 72, 6099-6106.
Invited article (Gary Posner Special Issue) - Selective Synthesis of Six Products from a Single Indole α-Diazocarbonyl Precursor
M J James, P O’Brien, R J K Taylor, W P Unsworth, Angew. Chem. Int. Ed., 2016, 55, 9671-9675. - Silica-Supported Silver Nitrate as a Highly Active Dearomatising Spirocyclisation Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica.
A K Clarke, M J James, P O’Brien, R J K Taylor, W P Unsworth, Angew. Chem. Int. Ed., 2016, 55, 13798-13802. - Phosphorylated Cyclopropanes in the Synthesis of α-Alkylidene-γ-butyrolactones: Total Synthesis of (±)-Savinin, (±)-Gadain and (±)-Peperomin E.
M G Lloyd, R J K Taylor, W P Unsworth, Org. Biomol. Chem., 2016, 14, 8971-8988. - Catalytic Dearomatization Approach to Quinolizidine Alkaloids: Five Step Total Synthesis of (±)-Lasubine II.
M J James, N Grant, P O’Brien, R J K Taylor, W P Unsworth, Org. Lett., 2016, 18, 6256-6259. - Preparation and Reactions of Indoleninyl Halides: Versatile Scaffolds for the Synthesis of Spirocyclic Indole Derivatives.
J T R Liddon, A K Clarke, R J K Taylor, W P Unsworth, Org. Lett., 2016, 18, 6328-6333.
2015
- Total Synthesis and Stereochemical Revision of Phacelocarpus 2-Pyrone A.
T O Ronson, M Burns, M H H Voelkel, K Evans, J M Lynam, R J K Taylor, I J S Fairlamb, Chem: Eur, J., 2015, online. - Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles.
M J James, R E Clubley, K Y Palate, T J Procter, A C Wyton, P O'Brien, R J K Taylor, W P Unsworth, Org. Lett., 2015, 17, 4372. - Synthetic Studies towards the Africanane Sesquiterpenes via the Cope Rearrangement of gem-Dimethyl-Substituted Divinyl Cyclopropanes.
J D Osler, W P Unsworth, R J K Taylor, Synlett, 26, online. - Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds.
M J James, J D Cuthbertson, P A O'Brien, R J K Taylor, W. P. Unsworth, Angew. Chemie Int. Ed., 2015, 54, 7640. - α-Alkylidene-γ-butyrolactone synthesis via one-pot C–H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B.
M G Lloyd, M D'Acunto, R J K Taylor, W P Unsworth, Tetrahedron, 2015, 71, 7107. - Substrate scope in the copper-mediated construction of bis-oxindoles via a double C-H/Ar-H coupling process.
P Drouhin, T E Hurst, A C Whitwood, R J K Taylor, Tetrahedron, 2015, 71, 7124. - The total synthesis of (+)-elaeokanidine A: natural product or isolation artefact?
J D Cuthbertson, W P Unsworth, C L Moody, R J K Taylor, Tetrahedron Lett., 2015, 56, 3123. - Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids.
G Coulthard, W P Unsworth, R J K Taylor, Tetrahedron Lett., 2015, 56, 3113. - Macrocyclic polyenynes: A stereoselective route to vinyl-ether-containing skipped diene systems.
T O Ronson, M H H Voelkel, R J K Taylor, I J S Fairlamb, Chem. Commun., 2015, 51, 8034. - A copper-mediated oxidative coupling route to 3H- and 1H-indoles from N-aryl-enamines.
P Drouhin, R J K Taylor, Eur. J. Org. Chem., 2015, 2333. - AsCat and FurCat: new Pd catalysts for selective room-temperature Stille cross-couplings of benzyl chlorides with organostannanes.
T O Ronson, J R Carney, A C Whitwood, R J K Taylor, I J S Fairlamb, Chem. Commun., 2015, 51, 3466. - Palladium-catalysed macrocyclisations in the total synthesis of natural products.
T O Ronson, R J K Taylor, I J S Fairlamb, Tetrahedron, 2015, 71, 989. - Special Memorial Issue for Professor Alan Katritzky.
R J K Taylor, Tetrahedron, 2015, 71, 7101.
2014
- A Direct C-H/Ar-H Coupling Approach to Oxindoles, Thio-oxindoles, 3,4-Dihydro-1 H-quinolin-2-ones, and 1,2,3,4-Tetrahydroquinolines.
T E Hurst, R M Gorman, P Drouhin, A Perry, and R J K Taylor, Chem. Eur. J., 2014, 20, 14063. - 4-Hydroxy-6-alkyl-2-pyrones as nucleophilic coupling partners in Mitsunobu reactions and oxa-Michael additions.
M J Burns, T O Ronson, R J K Taylor and I J S Fairlamb, Beilstein J. Org. Chem., 2014, 10, 1159. - Copper-Mediated Construction of Spirocyclic Bis-oxindoles via a Double C–H, Ar–H Coupling Process.
P Drouhin, T E Hurst, A C Whitwood, and R J K Taylor, Org. Lett., 2014, 16, 4900. - Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine.
C Kitsiou, W P Unsworth, G Coulthard, and R J K Taylor, Tetrahedron, 2014, 70, 7172. - A One-Pot C–H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones.
M G Lloyd, R J K Taylor and W P Unsworth, Org. Lett., 2014, 16, 2772. - Direct Imine Acylation for Molecular Diversity in Heterocyclic Synthesis.
W P Unsworth, G Coulthard, C Kitsiou, and R J K Taylor, J. Org. Chem., 2014, 79, 1368.
2013
- The Cope rearrangement of gem-dimethyl substituted divinylcyclopropanes.
J D Osler, W P Unsworth and R J K Taylor, Org. Biomol. Chem., 2013, 11, 7587. - ‘Upenamide: trials and tribulations.
W P Unsworth and R J K Taylor, Org. Biomol. Chem., 2013, 11, 7250. - Total Synthesis of Spirobacillene A.
W P Unsworth, J D Cuthbertson and R J K Taylor, Org. Lett., 2013, 15, 3306. - An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine.
W P Unsworth, C Kitsiou and R J K Taylor, Org. Lett., 2013, 15, 3302. - Stereocontrolled Synthesis of the AB Rings of Samaderine C.
D J Burns, S Mommer, P A O’Brien, R J K Taylor, A C Whitwood and S Hachisu, Org. Lett., 2013, 15, 394. - Stereocontrolled Routes to 4-Methoxypentadienoates for Use in Natural Product Synthesis.
P G E Craven and R J K Taylor, Synlett, 2013, 24, 363. - Direct Imine Acylation: Synthesis of the Proposed Structures of ‘Upenamide.
W P Unsworth, K A Gallagher, M l Jean, J P Schmidt, L J Diorazio and R J K Taylor, Org. Lett., 2013, 15, 262. - Direct Imine Acylation: Rapid Access to Diverse Heterocyclic Scaffolds.
W P Unsworth, C Kitsiou and R J K Taylor, Org. Lett., 2013, 15, 258. - A Telescoped Route to 2,6-Disubstituted 2,3,4,5-Tetrahydropyridines and 2,6-syn-Disubstituted Piperidines: Total Synthesis of (−)-Grandisine G.
J D Cuthbertson and R J K Taylor, Angew. Chemie Int. Ed., 2013, 52, 1490.
2012
- Catalytic asymmetric synthesis of butane diacetal-protected (4S,5S)-dihydroxycyclohexen-1-one and use in natural product synthesis.
D J Burns, Si Hachisu, P O'Brien and R J K Taylor, Org. Biomol. Chem., 2012, 10, 7666. - Total synthesis and structural confirmation of (±)-cuevaene A.
P G E Craven and R J K Taylor, Tetrahedron Lett., 2012, 53, 5422. - Preparation of 3-Alkylated Oxindoles from N-Benzyl Aniline via a Cu(II)-Mediated Anilide Cyclization Process.
D S Pugh, R J K Taylor, J S Alford and H M L Davies, Org. Synth., 2012, 89, 438. - An expedient synthesis of the proposed biosynthetic precursor of the oxepine natural product, janoxepin.
R G Doveston and R J K Taylor, Tetrahedron Lett., 2012, 53, 2533. - Total Synthesis of an Oxepine Natural Product, (±)-Janoxepin.
R G Doveston, R Steendam, S Jones and R J K Taylor, Org. Lett., 2012, 14, 1122. - Copper-catalysed approach to spirocyclic oxindoles via a direct C–H, Ar-H functionalisation.
C L Moody, V Franckevicious, P Drouhin, J E M N Klein and R J K Taylor, Tetrahedron Lett., 2012, 53, 1897. - Alkyne-Acetal Cyclisation Reactions Mediated by Formic Acid; 3-Acylated-2,5-dihydrofurans and Related Oxygen and Nitrogen Heterocycles.
J Cuthbertson, A Godfrey, W P Unsworth and R J K Taylor, Heterocycles, 2012, 84, 1013.
2011
- Formal synthesis of (+)-neooxazolomycin via a Stille cross-coupling/deconjugation route.
R Bastin, J W Dale, M G Edwards, J P N Papillon, M R Webb and R J K Taylor, Tetrahedron, 2011, 51, 10026. - Transition-Metal-Mediated Routes to 3,3-Disubstituted Oxindoles through Anilide Cyclisation.
J E M N Klein and R J K Taylor, Eur. J. Org. Chem., 2011, 6821. - Asymmetric Decarboxylative Allylation of Oxindoles.
V Franckevicius, J D Cuthbertson, M Pickworth, D S Pugh and R J K Taylor, Org. Lett., 2011, 13, 4264. - The Preparation of (−)-Grandisine B from (+)-Grandisine D; A Biomimetic Total Synthesis or Formation of an Isolation Artefact?
J Cuthbertson, A Godfrey and R J K Taylor, Org. Lett., 2011, 13, 3976. - Synthesis of isoquinuclidinones via a tandem amination/imination sequence: application to the synthesis of (−)-mearsine
J Cuthbertson, A Godfrey and R J K Taylor, Tetrahedron Lett., 2011, 52, 2024. - A one pot oxidation / allylation / oxidation sequence for the preparation of β,γ-unsaturated ketones directly from primary alcohols.
C L Moody, D S Pugh and R J K Taylor, Tetrahedron Lett., 2011, 52, 2511. - Tetra-[μ]2-acetato-diacetatodi-[μ]3-hydroxido-tetrakis[piperidinecopper(II)] dihydrate.
J E M N Klein, R J Thatcher, A C Whitwood and R J K Taylor, Acta Cryst. C, 2011, 67, m108-m110. - Synthesis of yomogin using a telescoped α-methylene- γ-butyrolactone annelation procedure.
R Kitson, G McAllister and R J K Taylor, Tetrahedron Lett., 2011, 52, 561. - The First Syntheses of (±)-SDEF 678 Metabolite and (±)-Speciosins A–C.
D R Hookins, A R Burns and R J K Taylor, Eur. J. Org. Chem., 2011, 451. - Synthetic Approaches to Enantiomerically Enriched 4-Hydroxycyclohex-2-en-1-one - A Key Chiral Building Block in Complex Natural Product Synthesis.
A R Burns and R J K Taylor, Synthesis, 2011, 681.
2010
- A double oxidation procedure for the preparation of halogen-substituted para-benzoquinone monoketals: Asymmetric synthesis of (-)-harveynone.
D R Hookins and R J K Taylor, Tetrahedron Lett., 2010, 51, 6619. - A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones.
J D Cuthbertson, A A Godfrey and R J K Taylor, Synlett, 2010, 2805. - Pd-catalysed regioselective C–H functionalisation of 2-pyrones.
M J Burns, R J Thatcher, R J K Taylor and I J S Fairlamb, Dalton Trans., 2010, 10391. - Highly regio- and chemoselective palladium(0)-mediated allylic substitution of difunctional allylic halides with phenols.
A R Kapdi, R J K Taylor and I J S Fairlamb, Tetrahedron Lett., 2010, 51, 6378. - First C−H Activation Route to Oxindoles using Copper Catalysis.
J E M N Klein, A Perry, D S Pugh and R J K Taylor, Org. Lett., 2010, 12, 3446. - 3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches.
A Millemaggi and R J K Taylor, Eur. J. Org. Chem., 2010, 4527 (front cover). - Total Synthesis and Structural Reassignment of (+)-Dictyosphaeric Acid A: A Tandem Intramolecular Michael Addition/Alkene Migration Approach.
A R Burns, G D McAllister, S E Shanahan and R J K Taylor, Angew. Chemie Int. Ed., 2010, 49, 5574. - Recent Advances in the Chemistry of 1,2,4-Triazines.
S A Raw and R J K Taylor in "Advances in Heterocyclic Chemistry", ed A R Katritzky, Elsevier, Oxford, 2010, 75-100. - Tandem Horner-Wadsworth-Emmons Heck procedures for the preparation of 3-alkenyl-oxindoles: The synthesis of semaxanib and GW441756.
J Lubkoll, A Millemaggi, A Perry and R J K Talyor, Tetrahedron, 2010, 66, 6606. - Preparation of 3-Alkyl-Oxindoles by Copper(II)-Mediated C-H, Ar-H Coupling Followed by Decarboxyalkylation.
D S Pugh, J E M N Klein, A Perry and R J K Taylor, Synlett, 2010, 934-938. - The Emergence of Palladium(IV) Chemistry in Synthesis and Catalysis.
I J S Fairlamb, P Sehnal and R J K Taylor, Chem. Rev. 2010, 110, 824-889. - The Preparation of Substituted Pyrazoles from β,β-Dibromo-enones by a Tandem Condensation/Suzuki-Miyaura Cross-Coupling Process.
S Beltrán-Rodil, M G Edwards, D S Pugh, M Reid and R J K Taylor, Synlett, 2010, 602-606.
2009 to 2000
2009 2008 2007 2006 2005 2004 2003 2002 2001 2000
2009
- A One-Pot, Base-Free Annelation Approach to α -Alkylidene α -Butyrolactones.
R R A Kitson, R J K Taylor and J L Wood, Org. Lett., 2009, 11, 5338-5341. - Synthesis of the Louisianin Alkaloid Family via a 1,2,4-Triazine-Based Inverse Electron Demand Diels-Alder Approach.
N Catozzi, M G Edwards, S A Raw, P Wasnaire and R J K Taylor, J. Org. Chem., 2009, 74, 8343-8354. - The Renaissance of α-Methylene-α-butyrolactones: New Synthetic Approaches.
R R A Kitson, A Millemaggi and R J K Taylor, Angew. Chemie Int. Ed., 2009, 48, 9426-9451. - Telescoped Enolate Arylation / HWE Procedure for 3-Alkenyl-Oxindole Preparation; The First Synthesis of Soulieotine.
A Millemaggi, A Perry and R J K Taylor, Eur. J. Org. Chem., 2009, 2947-2952. - Oxindole Synthesis by Direct C-H, Ar-H Coupling.
A Perry and R J K Taylor, Chem. Commun., 2009, 3249-3251. - Tandem Retro-Aldol / Wittig / Michael and Related Cascade Processes.
S Beltrán-Rodil, J R Donald, M G Edwards, S A Raw and R J K Taylor, Tetrahedron Lett., 2009, 50, 3378-3380. - Gem-Dimethylcyclopropanation of Dibenzylideneacetone using Triisopropylsulfoxonium Tetrafluoroborate.
M G Edwards, D S Pugh, A C Whitwood and R J K Taylor, Acta Cryst. C, 2009, 65, o39-o41. - Tandem Meinwald Rearrangement / Fischer Indolisation: A One Pot Conversion of Epoxides into Indoles.
J R Donald and R J K Taylor, Synlett, 2009, 59-62. - Suzuki-Miyaura Cross-Couplings Mediated by trans-PdBr(N-Succ)(PPh3)2: A Convenient Synthetic Method for Diaryl- and Aryl(heteroaryl)methanes.
I J S Fairlamb, P Sehnal and R J K Taylor, Synthesis, 2009, 508-510.
2008
- The Preparation of Novel Polycyclic Heterocycles Using a Stannous Chloride Dihydrate-Mediated Deacetalisation / Bicyclisation Sequence.
A N Cayley, K A Gallagher, C Ménard-Moyon, J P Schmidt, L J Diorazio and Richard J K Taylor, Synthesis, 2008, 3846-3856. - The Preparation of α-Alkylidene α-Butyrolactones using a Telescoped Intramolecular Michael / Olefination (TIMO) Sequence: Synthesis of (+)-Paeonilactone B.
M G Edwards, M N Kenworthy, R R A Kitson, A Perry, M Scott, A C Whitwood and R J K Taylor, Eur. J. Org. Chem., 2008, 4769-4783. - Gem-Dimethylcyclopropanation using Triisopropylsulfoxonium Tetrafluoroborate: Scope and Limitations.
M G Edwards, R J Paxton, D S Pugh, A C Whitwood and R J K Taylor, Synthesis, 2008, 3279-3288. - The Conversion of Carbonyl Compounds into Pentadienylamines by a Julia-Kocienski Olefination Procedure.
R Bastin, M Liron and R J K Taylor, Synlett, 2008, 2183-218 - An Efficient 1,2,4-Triazine-based Route to the Louisianin Alkaloids.
N Catozzi, P Wasnaire and R J K Taylor, Tetrahedron Lett., 2008, 49, 2865-2868. - An Improved gem-Dimethylcyclopropanation Procedure using Triisopropylsulfoxonium Tetrafluoroborate.
M G Edwards, R J Paxton, D S Pugh and R J K Taylor, Synlett, 2008, 521-524. - The syntheses of rac-inthomycin A, (+)-inthomycin B and (+)-inthomycin C using a unified synthetic approach.
M R Webb, M S Addie, C M Crawforth, J W Dale, X Franci, M Pizzonero, C Donald and R J K Taylor, Tetrahedron, 2008, 64, 4778-4791. - Diaziridines and Diazirines.
G D McAllister, A Perry and R J K Taylor, in "Volume 1 of Comprehensive Heterocyclic Chemistry III", ed. A R Katritzky, C A Ramsden, E F V Scriven and R J K Taylor, Elsevier, Oxford, 2008, 539-557. - A Convergent Synthesis of the Tricyclic Core of the Dictyosphaeric Acid.
C W Barfoot, A R Burns, M G Edwards, M N Kenworthy, M Ahmed, S E Shanahan and R J K Taylor, Org. Lett., 2008, 10, 353-356. - The telescoped intramolecular Michael / olefination (TIMO) approach to α-alkylidene γ-butyrolactones: Synthesis of (+)-paeonilactone B.
M G Edwards, M N Kenworthy, R R A Kitson, M Scott and R J K Taylor, Angew. Chemie Int. Ed., 2008, 47, 1935-1937. - (±)-Diethyl (E,E,E)-Cyclopropane-1,2-acrylate; Tandem Oxidation Procedure (TOP) Using MnO2 Oxidation-Stabilised Phosphorane Trapping.
R J K Taylor, L Blackburn and G D McAllister, Org. Synth., 2008, 85, 15-26.
2007
- The Preparation of Highly Substituted Pyridazines via a Tethered Imine-Enamine (TIE) Procedure.
P H Geyelin, S A Raw and R J K. Taylor, Arkivoc, 2007, xi,37-45. - Improved Dimethylsulfoxonium Methylide Cyclpropanation Procedures Including a Tandem Oxidation Variant.
R J Paxton and R J K Taylor, Synlett, 2007, 633-637. - A Ramberg-Bäcklund Route to the Stilbenoid Anti-cancer Agents Combretastatin A-4 and DMU-212.
J E Robinson and R J K Taylor, Chem. Commun., 2007, 1617-1619. - Tandem Inverse Electron Demand Diels-Alder, Retro- Diels-Alder and Intramolecular Diels-Alder Sequences: One Pot Synthesis of Diaza-polycycles.
W J Bromley, M Gibson, S Lang, S A Raw, A C Whitwood and R K Taylor; Tetrahedron, 2007, 63, 6004-6014. - Stereoselective Syntheses of the Octahydropyrano[2,3-b]pyridine DE Core of ’Upenamide via a Stannous Chloride-Induced Deacetalisation–Cyclisation Procedure.
C Ménard-Moyon and R J K Taylor, Eur. J. Org.Chem., 2007, 3698-3706. - Tandem Oxime Formation – Epoxide Ring Opening Sequences for the Preparation of Oxazines Related to the Trichodermamides.
J R Donald, M G Edwards and R J K Taylor, Tetrahedron Lett., 2007, 48, 5201-5204. - Deacetalisation-Bicyclisation Routes to Novel Polycyclic Heterocycles Using Stannous Chloride Dihydrate.
A N Cayley, R J Cox, C Ménard-Moyon, J P Schmidt and R J K Taylor, Tetrahedron Lett., 2007, 48, 6556-6560. - Improved and Practical Procedures for the Preparation of Highly Substituted Pyridines and Pyridazines via Silica-Mediated Aromatization.
N Catozzi, W J Bromley, P Wasnaire, M Gibson and R J K Taylor, Synlett, 2007, 2217-2221. - The first synthesis of the ABC-ring system of ‘upenamide.
J P Schmidt, S Beltrán-Rodil, R J Cox, G D McAllister, M Reid and R J K Taylor; Org. Lett., 2007, 9, 4041-4044. - A simple palladium(II) precatalyst for Suzuki-Miyaura couplings: efficient reactions of benzylic, aryl, heteroaryl and vinyl coupling partners.
M J Burns, I J S Fairlamb, A R Kapdi, P Sehnal and R J K Taylor, Org. Lett., 2007, 9, 5397-5400. - The synthesis of (-)-varitriol and (-)-3'-epi-varitriol via a Ramberg-Bäcklund route.
G D McAllister, J E Robinson and R J K Taylor, Tetrahedron, 2007, 63, 12123-12130.
2006
- New synthetic methodologies to functional groups important in fragrance compounds.
R J K Taylor, M Reid, and S B Jameson, Foods Food Ingred J Jap, 2006, 211, 595-601. - Total synthesis of 6-deoxyclitoriacetal isolated from Stemona collinsae Craib.
P Khorphueng, J Tummatorn, A Petsom, R J K Taylor, and S Roengsumran, Tetrahedron Lett, 2006, 47, 5989-5991. - Tandem oxidation-Wittig-Wittig sequences for the preparation of functionalized dienoates.
S Lang and R J K Taylor, Tetrahedron Lett, 2006, 47, 5489-5492. - The direct preparation of functionalized cyclopropanes from allylic alcohols or α-hydroxy ketones using tandem oxidation processes.
G D McAllister, M F Oswald, R J Paxton, S A Raw and R J K Taylor, Tetrahedron, 2006, 62, 6681-6694. - Halide and pseudohalide effects in Pd-catalysed cross-coupling reactions.
I J S Fairlamb, R J K Taylor, J L Serrano and G Sanchez, New J Chem, 2006, 30, 1695-1704. - One-pot conversion of activated alcohols into 1,1-dibromoalkenes and terminal alkynes using tandem oxidation processes with manganese dioxide.
E Quesada, S A Raw, M Reid, E Roman and R J K Taylor, Tetrahedron, 2006, 62, 6673-6680. - The Ramberg-Bäcklund reaction for the synthesis of C-glycosides, C-linked-disaccharides and related compounds.
R J K Taylor, G D McAllister and R W Franck, Carbohydr Res, 2006, 341, 1298-1311. - Tandem oxidation processes for the regioselective preparation of 5-substituted and 6-substituted 1,2,4-triazines.
S Laphookhieo, S Jones, S A Raw, Y F Sainz and R J K Taylor, Tetrahedron Lett, 2006, 47, 3865-3870. - The epoxy-Ramberg-Bäcklund reaction (ERBR): a sulfone-based method for the synthesis of allylic alcohols.
P Evans, P Johnson and R J K Taylor, Eur. J. Org. Chem., 2006, 1740-1754. - Air-stable, phosphine-free anionic palladacyclopentadienyl catalysts: remarkable halide and pseudohalide effects in stille coupling.
C M Crawforth, I J S Fairlamb, A R Kapdi, J L Serrano, R J K Taylor and G Sanchez, Adv Synth Catal, 2006, 348, 405-412. - A general route to Streptomyces-derived inthomycin family: The first synthesis of (+)-inthomycin B.
M R Webb, C Donald and R J K Taylor, Tetrahedron Lett 2006, 47, 549-552.
2005
- Conjugate addition reactions of vinyl sulfones with hard nucleophiles.
P Evans and R J K Taylor, J Sulfur Chem, 2005, 26, 481-497. - Tandem Horner-Wadsworth-Emmons olefination/ Claisen rearrangement/ hydrolysis sequence: Remarkable acceleration in water with microwave irradiation.
E Quesada, and R J K Taylor, Synthesis, 2005, 3193-3195. - A protecting group-free approach to C-glycosides using the Ramberg–Bäcklund reaction.
S Jeanmart and R J K Taylor, Tetrahedron Lett, 2005, 46, 9043-9048. - Improved Methodologies for the Preparation of Highly Substituted Pyridines.
Y Fernández Sainz, S A Raw and R J K Taylor, J Org Chem 2005, 70, 10086-10095. - Oxidative addition of N-halosuccinimides to palladium(0): the discovery of neutral palladium(II) imidate complexes, which enhance Stille coupling of allylic and benzylic halides.
C M Crawforth, S Burling, I J S Fairlamb, A R Kapdi, R J K Taylor, and A C Whitwood, Tetrahedron, 2005, 61, 9736-9751. - Tandem Oxidation Processes Using Manganese Dioxide: Discovery, Applications, and Current Studies.
R J K Taylor, M Reid, M., J Foot and S A Raw, Acc Chem Res, 2005, 38, 851-869. - One-pot conversion of activated alcohols into terminal alkynes using manganese dioxide in combination with the Bestmann-Ohira reagent.
E Quesada,and R J K Taylor, Tetrahedron Lett, 2005, 46, 6473-6476. - Tandem oxidation processes: a combined phosphorus- and sulfur-ylide approach to polysubstituted cyclopropanes.
M F Oswald, S A Raw and R J K Taylor, Chem. Commun. 2005, 2253-2255. - Quinoxaline synthesis from alpha-hydroxy ketones via a tandem oxidation process using catalysed aerobic oxidation.
R S Robinson and R J K Taylor, Synlett, 2005, 1003-1005. - Synthesis of the Eastern Portion of Ajudazol A Based on Stille Coupling and Double Acetylene Carbocupration.
O Krebs and R J K Taylor, Org Lett, 2005, 7, 1063-1066. - Highly functionalised organolithium and organoboron reagents for the preparation of enantiomerically pure -amino acids.
C W Barfoot, J E Harvey, M N Kenworthy, J P Kilburn, M Ahmed and R J K Taylor, Tetrahedron, 2005, 61, 3403-3417. - Generation and interrogation of a pure nuclear spin state by parahydrogen-enhanced NMR spectroscopy:
a defined initial state for quantum computation.
D Blazina, S B Duckett, T K Halstead, C M Kozak, R J K Taylor, M S Anwar, J A Jones and H A Carteret, Magn. Res. Chem., 2005, 43, 200-208. - Unexpected Z-stereoselectivity in the Ramberg-Bäcklund reaction of diarylsulfones leading to cis-stilbenes: the effect of aryl substituents and application in the synthesis of the integrastatin nucleus.
J S Foot, G M P Giblin, A C Whitwood and R J K Taylor, Org Biomol Chem, 2005, 3, 756-763.
2004
- Cascade reactions of 1,2,4-triazines: direct thermochemical access to functionalized 4,5-dihydroazocines.
S A Raw and R J K Taylor, Tetrahedron Lett, 2004, 45, 8607-8610. - Cascade reactions of substituted 1,2,4-triazines: Rapid access to nitrogen-containing polycycles.
S A Raw and R J K Taylor, J. Am. Chem. Soc. 2004, 126, 12260-12261. - The preparation of simplified scyphostatin analogues using a tethered aminohydroxylation (TA) strategy.
M N Kenworthy, G D McAllister and R J K Taylor, Tetrahedron Lett, 2004, 45, 6661-6664. - Preparation of 2-substituted benzimidazoles and related heterocycles directly from activated alcohols using TOP methodology.
C D Wilfred and R J K Taylor, Synlett, 2004, 1628-1630. - A versatile, non-biomimetic route to the preussomerins: syntheses of (+/-)-preussomerins F, K and L.
E Quesada, M Stockley, J P Ragot, M E Prime, A C Whitwood and R J K Taylor, Org Biomol Chem 2004, 2, 2483-2495. - Bis(triphenylphosphine)palladium(II)phthalimide - an easily prepared precatalyst for efficient Suzuki-Miyaura coupling of aryl bromides.
N M Chaignon, I J S Fairlamb, A R Kapdi, R J K Taylor and A C Whitwood, J Mol Cat A, 2004, 219, 191-199. - Preparing high purity initial states for nuclear magnetic resonance quantum computing.
M S Anwar, D Blazina, H A Carteret, S B Duckett T K Halstead, J A Jones, C M Kozak and R J K Taylor, Phys Rev Lett, 2004, 93, 040501. - A versatile and stereocontrolled route to pyranose and furanose C-glycosides.
J E Harvey, S A Raw and R J K Taylor, Org Lett, 2004, 6, 2611-2614. - Palladacyclopentadiene complexes with mono- and didentate imidato ligands: Synthesis, hemilabile behaviour and catalytic application in the Stille reaction.
J L Serrano, I J S Fairlamb, G Sanchez, L Garcia, J Perez, J Vives, G Lopez, C M Crawforth and R J K Taylor, Eur. J. Inorg. Chem., 2004, 2706-2715. - Bis(triphenylphosphine)palladium(II)succinimide as a precatalyst for Suzuki cross-coupling-subtle effects exerted by the succinimide ligand.
I J S Fairlamb, A R Kapdi, J M Lynam, R J K Taylor and A C Whitwood, Tetrahedron, 2004, 60, 5711-5718. - The first total syntheses of (+/-)-preussomerins K and L using 2-arylacetal anion technology.
E Quesada, M Stockley and R J K Taylor, Tetrahedron Lett, 2004, 45, 4877-4881. - A stannous chloride-indued deacetalisation-cyclisation process to prepare the ABC ring system of upenamide.
M Reid and R J K Taylor, Tetrahedron Lett, 2004, 45, 4181-4183. - A Tandem Oxidation Procedure for the Conversion of Alcohols into 1,1-Dibromoalkenes.
S A Raw, M Reid, E Roman and R J K Taylor, Synlett, 2004, 819-822. - 4-Bromomethyl-2-chlorooxazole -a versatile oxazole cross-coupling unit for the synthesis of 2,4-disubstituted oxazoles.
G L Young, S A Smith and R J K Taylor, Tetrahedron Lett, 2004, 45, 3797-3801. - New solid-supported phosphonate reagents for the synthesis of Z-a,b-unsaturated esters.
S L X Martina and R J K Taylor, Tetrahedron Lett, 2004, 45, 3279-3282. - Tandem oxidation processes for the preparation of nitrogen-containing heteroaromatic and heterocyclic compounds.
S A Raw, C D Wilfred and R J K Taylor, Org Biomol Chem, 2004, 2, 788-796. - Lithium enolates from a (-)quinic acid-derived cyclohexanone with a b-alkoxy leaving group: regioselective preparation and evaluation of enolate stability towards b-elimination.
L M Murray, P O'Brien, R J K Taylor and S Wünnemann, Tetrahedron Lett, 2004, 45, 2597-2601. - An improved synthesis of the Scyphostatin side-chain.
G D McAllister and R J K Taylor, Tetrahedron Lett, 2004, 45, 2551-2554. - Synthesis of non-proteinogenic phenylalanine analogues by Suzuki cross-coupling of a serine-derived alkyl boronic acid.
J E Harvey, M N Kenworthy and R J K Taylor, Tetrahedron Lett, 2004, 45, 2467-2471. - Highly Substituted Pyridines via Tethered Enamine-Imine Methodology.
S A Raw and R J K Taylor, Chem Commun, 2004, 508-509. - Highly functionalised organolithium reagents for enantiomerically pure a-amino acid synthesis.
M N Kenworthy, J P Kilburn and R J K Taylor, Org Lett, 2004, 6, 19-22. - Efficient and selective Stille cross-coupling of benzilic and allylic bromides using bromobis(triphenylphosphine)(N-Succinimide)palladium(II).
C M Crawfoth, I J S Fairlamb and R J K Taylor, Tetrahedron Lett, 2004, 45, 461-465.
2003
- Synthesis of the Integrastatin nucleous using the Ramberg-Bäcklund reaction.
J S Foot, M P Giblin and R J K Taylor, Org Lett, 2003, 5, 4441-4444. - A comparison of the Still-Gennari and Ando HWE-methodologies with α,β-unsaturated aldehydes; unexpected results with stannyl substituted systems.
X Franci, S L X Martina, J E McGrady, M R Webb, C Donald and R J K Taylor, Tetrahedron Lett, 2003, 44, 7735-7740. - The first synthesis of the epoxide-containing macrolactone nucleus of oximidine I.
J E Harvey, S A Raw and R J K Taylor, Tetrahedron Lett, 2003, 44, 7209-7212. - Preparation of quinoxalines, dihydropyrazines, pyrazines and piperazines using tandem oxidation processes.
S A Raw, C D Wilfred and R J K Taylor, Chem Commun, 2003, 2286-2287. - Two carbon homologated α,β-unsaturated aldehydes from alcohols using the in situ oxidation-Wittig reaction.
M Reid, D J Rowe and R J K Taylor, Chem Commun, 2003, 2284-2285. - Bromo(triphenylphosphine)(N-Succinimide)Palladium (II) as a novel catalyst for Stille cross-coupling reactions.
C M Crawforth, S Burling, I J S Fairlamb, R J K Taylor and A C Whitwood, Chem Commun, 2003, 2194-2195. - Stereoselective Reactions of a (-)-Quinic Acid-Derived Enone: Application to the Synthesis of the Core of Scyphostatin.
L M Murray, P O'Brian and R J K Taylor, Org Lett, 2003, 11, 1943-1946. - Esters from Activated Alcohols using Manganese (IV) Dioxide: Tandem Oxidation Processes.
J S Foot, H Kanno, G M P Giblin and R J K Taylor, Synthesis, 2003, 1055-1063. - A simplified Ramberg-Bäcklund approach to novel C-glycosides and C-linked disaccharides.
G D McAllister, D E Paterson and R J K Taylor, Angew Chem Int Ed, 2003, 42, 1387-1391. - Confirmation of the structure of a gluco-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone.
P V Murphy, C McDonnell, L Hamig, D E Paterson and R J K Taylor, Tetrahedron Asymm, 2003, 14, 79-85. - Enantiopure Guanidine Bases for Enantioselective Enone Epoxidations: 2, Cyclic Guanidines.
J C McManus, T Genski, J S Carey and R J K Taylor, Synlett, 2003, 369-371. - Enantiopure Guanidine Bases for Enantioselective Enone Epoxidations: 1, Acyclic Guanidines.
J C McManus, J S Carey and R J K Taylor, Synlett, 2003, 3, 365-368. - A Formal Total Synthesis of (+)-Apicularen A: Base-induced Conversion of Apicularen-Derived Intermediates into Salicylihalamide-like Products.
A Lewis, I Stefanuti, S A Swain and R J K Taylor, Org Biomol Chem,2003, 1, 104-116. - In Situ Alcohol Oxidation - Wittig Reactions using N-Methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide: Application to the Synthesis of a Novel Analogue of 5-Oxo-eicosatetraenoic Acid.
L Blackburn, H Kanno and R J K Taylor, Tetrahedron Lett, 2003, 44, 115-118.
2002
- A One-Pot Oxidation - Imine Formation - Reduction Route from Alcohols to Amines using Manganese Dioxide and Sodium Borohydride: The Synthesis of Naftifine.
H Kanno and R J K Taylor, Tetrahedron Lett, 2002, 43, 7337-7340. - In Situ Oxidative Diol Cleavage - Wittig Processes.
H S Outram, S A Raw and R J K Taylor, Tetrahedron Lett, 2002, 43, 6185-6187. - Hydroboration - Suzuki Cross Coupling of Unsaturated Amino Acids; The Synthesis of Pyrimine Derivatives.
P N Collier, A D Campbell, I Patel and R J K Taylor, Tetrahedron, 2002, 58, 6117-6125. - Tandem Oxidation Processes: The Direct Conversion of Activated Alcohols into Esters and Amides.
J S Foot, H Kanno, G M P Giblin and R J K Taylor, Synlett, 2002, 2, 1293-1295. - Tandem Oxidation Processes: The Direct Conversion of Activated Alcohols into Nitriles.
G D McAllister, C D Wilfred and R J K Taylor, Synlett, 2002, 2, 1291-1292. - Tandem Oxidation Processes: The Direct Conversion of Activated Alcohols into Oximes; Synthesis of Citaldoxime.
H Kanno and R J K Taylor, Synlett, 2002, 2, 1287-1290. - The Synthesis of Epi-Epoxydon Utilising the Baylis-Hillman Reaction.
T Genski and R J K Taylor, Tetrahedron Lett, 2002, 43, 3573-3576. - The In Situ Oxidation-Wittig Reaction of alpha-Hydroxyketones.
K A Runcie and R J K Taylor, Chem Commun, 2002, 974-975. - Heck reactions of amino acid building blocks: application to the synthesis of pyrrololine analogues.
P N Collier, I Patel and R J K Taylor, Tetrahedron Lett, 2002, 43, 3401-3405. - A Ramberg-Bäcklund Approach to the Synthesis of C-Glycosides, C-Linked Disaccharides and C-Glycosyl Amino Acids.
D E Paterson, F K Griffin, M L Alcaraz and R J K Taylor, Eur J Org Chem, 2002, 1323-1336. - A New Route to exo-Glycals using the Ramberg-Bäcklund Rearrangements.
F K Griffin, D E Paterson, P V Murphy and R J K Taylor, Eur J Org Chem, 2002, 1305-1322. - Enantiomerically pure alpha-amino acid synthesis via Hydroboration-Suzuki Cross-Coupling.
P N Collier, A D Campbell, I Patel, T M Raynham and R J K Taylor, J Org Chem, 2002, 67, 1802-1815. - In Situ Alcohol Oxidation-Wittig Reactions using Non-Stabilised Phosphoranes.
L Blackburn, C Pei and R J K Taylor, Synlett, 2002, 215-218. - The preparation of nonracemic secondary alpha-(carbamoyloxy)alkylzinc and copper reagents. A versatile approach to enantioenriched alcohols.
J P N Papillon and R J K Taylor, Org Lett, 2002, 4, 119-122 .
2001
- A short and efficient route to novel scyphostatin analogues.
K A Runcie and R J K Taylor, Org Lett, 2001, 3, 3237-3239. - A concise, stereoselective synthesis of meso-2,6-diaminopimelic acid (DAP).
P N Collier, I Patel and R J K Taylor, Tetrahedron Lett, 2001, 42, 5953-5954. - Carbohydrate-based routes to salicylate natural products: formal total synthesis of (+)-apicularen A from D-glucal.
A Lewis, I Stefanuti, S A Swain, S A Smith and R J K Taylor, Tetrahedron Lett, 2001, 42, 5549-5552. - In situ oxidation-imine formation-reduction routes from alcohols to amines.
L Blackburn and R J K Taylor, Org Lett, 2001, 3, 1637-1639. - The synthesis of polyoxygenated, enantiopure cyclopentene derivatives using the Ramberg-Bäcklund rearrangement.
G D McAllister and R J K Taylor, Tetrahedron Lett, 2001, 42, 1197-1200.
2000
- Approaches to oximidines, lobatamides and related natural products: the coupling reactions of 3-iodoacrolein O-methyl oximes.
S A Raw and R J K Taylor, Tetrahedron Lett., 2000, 41, 10357-10361. - The stereoselective preparation of substituted pyrrolidines using titanium- and zirconium-mediated diene metallabicyclisation methodology: the total synthesis of (-)-alpha-kainic acid.
A D Campbell, T M Raynham and R J K Taylor, J. Chem. Soc. Perkin Trans. 1 2000, 3194-3204. - The direct synthesis of novel enantiomerically pure alpha-amino acids in protected form via Suzuki cross-coupling.
P N Collier, A D Campbell, I Patel and R J K Taylor Tetrahedron Lett. 2000, 41, 7115-7119. - The first syntheses of the 1-oxo-2-oxa-5-azaspiro[3.4]octane ring system found in oxazolomycin.
J P B Papillon and R J K Taylor, Org. Lett. 2000, 2, 1987-1990. - A novel route to preussomerins via 2-arylacetal anions.
J P Ragot, M E Prime, S J Archibald and R J K Taylor, Org. Lett. 2000, 2, 1613-1616. - Unsaturated enamides via organometallic addition to isocyanates: the synthesis of Lansamide-I, Lansiumamides A-C and SB-204900.
I Stefanuti, S A Smith and R J K Taylor, Tetrahedron Lett. 2000, 40, 3735-3738. - The enantioselective epoxidation of quinones using sugar hydroperoxides.
C L Dwyer, C D Gill, O Ichihara and R J K Taylor, Synlett 2000, 704-706. - Organolithium addition to styrene and styrene derivatives: scope and limitations.
X D Wei, P Johnson and R J K Taylor, J. Chem. Soc., Perkin Trans. 1 2000, 1109-1116. - New routes to 5-substituted oxazoles.
M S Addie and R J K Taylor, J. Chem. Soc. Perkin Trans. 1 2000, 527-531. - Tandem intermolecular-intramolecular carbolithiation: A versatile method for synthesis of cyclopentanes.
X D Wei and R J K Taylor, Angew. Chem. Int. Ed. 2000, 39, 409-412. - In situ manganese dioxide alcohol oxidation-Wittig reactions: Preparation of bifunctional dienyl building blocks.
X D Wei and R J K Taylor, J. Org. Chem. 2000, 65, 616-620. - 1,3-Dienes from ketones via the Shapiro reaction.
M S Addie and R J K Taylor, ARKIVOC 2000, 1, 660-666. - Synthesis and application of novel bicyclic guanidines: N-alkylation of 1,5,7-triazabicyclo[4.4.0]dec-5-ene.
T Genski, G Mcdonald, X Wei, N Lewis and R J K Taylor ARKIVOC 2000, 1, 266-273.
1999 to 1995
1999
- The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria.
B R S Ali, A Pal, S L Croft, R J K Taylor and M C Field, Mol. Biochem. Parasit. 1999, 104, 67-80. - Ramberg-Bäcklund approaches to the synthesis of C-linked disaccharides.
F K Griffin, D E Paterson and R J K Taylor, Angew. Chem. Int. Ed. 1999, 38, 2939-2942. - Manganese dioxide can oxidise unactivated alcohols under in situ oxidation-Wittig conditions.
L Blackburn, X D Wei and R J K Taylor Chem. Commun. 1999, 1337-1338. - Exo-glycal approaches to C-linked glycosyl amino acid synthesis.
A D Campbell, D E Paterson, T M Raynham and R J K Taylor, Chem. Commun. 1999, 1599-1600. - Epoxidation of electron deficient alkenes using tert-butyl hydroperoxide and 1,5,7-triazabicyclo[4.4.0]dec-5-ene and its derivatives.
T Genski, G Macdonald, X D Wei and R J K Taylor, Synlett 1999, 795-797. - The synthesis of novel amino acids via hydroboration-Suzuki cross coupling.
A D Campbell, T M Raynham and R J K Taylor, Tetrahedron Lett. 1999, 40, 5263-5266. - The first total synthesis of (+/-)-colabomycin D.
X D Wei, J J C Grove and R J K Taylor, J. Chem. Soc., Perkin Trans. 1 1999, 1143-1145. - Eight membered ethers via diene metathesis: Synthetic approach to laureatin natural products.
S D Edwards, T Lewis and R J K Taylor, Tetrahedron Lett. 1999, 40, 4267-4270. - The synthesis of 1,8-dihydroxynaphthalene-derived natural products: palmarumycin CP1, palmarumycin CP2, palmarumycin C-11, CJ-12,371, deoxypreussomerin A and novel analogues.
J P Ragot, C Steeneck, M L Alcaraz and R J K Taylor, J. Chem. Soc., Perkin Trans. 1 1999, 1073-1082. - The first total synthesis of a type II manumycin antibiotic, (+)-TMC-1A: the total syntheses of (-)-LL-C10037 beta and (+)-manumycin B.
J J C Grove, X D Wei and R J K Taylor, Chem. Commun. 1999, 421-422. - Synthetic approaches to the manumycin A, B and C antibiotics: The first total synthesis of (+)-manumycin A.
L Alcaraz, G Macdonald, J Ragot, N J Lewis and R J K Taylor, Tetrahedron 1999, 55, 3707-3716. - Recent developments in Ramberg-Bäcklund and episulfone chemistry.
R J K Taylor, Chem. Commun. 1999, 217-227. - The total synthesis of (-)-alpha-kainic acid using titanium-mediated diene metallabicyclisation methodology.
A D Campbell, T M Raynham and R J K Taylor, Chem. Commun. 1999, 245-246.
1998
- A simplified route to the (R)-Garner aldehyde and (S)-vinyl glycinol.
A D Campbell, T M Raynham and R J K Taylor Synthesis 1998, 1707-1709. - The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x).
P V Murphy, R E Hubbard, D T Manallack, R E Wills, J G Montana and R J K Taylor Bioorg. Med. Chem. 1998, 6, 2421-2439. - A Ramberg-Bäcklund approach to exo-glycals.
F K Griffin, P V Murphy, D E Paterson and R J K Taylor Tetrahedron Lett. 1998, 39, 8179-8182. - Synthetic applications of Ramberg-Bäcklund derived exo-glycals.
M L Alcaraz, F K Griffin, D E Paterson and R J K Taylor Tetrahedron Lett. 1998, 39, 8183-8186. - Unsaturated amides derived from 2-amino-3-hydroxycyclopentenone: A Stille approach to the synthesis of Asuka-mABA, 2880-II, and limocrocin.
G Macdonald, L Alcaraz, X D Wei and R J K Taylor Tetrahedron 1998, 54, 9823-9836. - Asymmetric synthesis of the mC(7)N core of the manumycin family: Preparation of (+)-MT35214 and a formal total synthesis of (-)-alisamycin.
G Macdonald, L Alcaraz, N J Lewis and R J K Taylor Tetrahedron Lett. 1998, 39, 5433-5436. - Manumycin A: Synthesis of the (+)-enantiomer and revision of stereochemical assignment.
Alcaraz L., Macdonald G., Ragot J.P., Taylor R.J.K. J. Org. Chem. 1998, 63, 3526-3527. - Syntheses of palmarumycin CP1 and CP2, CJ-12,371 and novel analogues.
J P Ragot, M L Alcaraz and R J K Taylor Tetrahedron Lett. 1998, 39, 4921-4924. - The first synthesis of the Streptomyces derived antibiotic U-62162.
L Alcaraz and R J K Taylor Chem. Commun. 1998, 1157-1158. - The synthesis of alisamycin, nisamycin, LL-C10037 alpha and novel epoxyquinol and epoxyquinone analogues of manumycin A.
R J KTaylor, L Alcaraz, I Kapfer-Eyer, G Macdonald, X D Wei, and N Lewis Synthesis 1998, 775-790. - In situ alcohol oxidation Wittig reactions.
X D Wei and R J K Taylor Tetrahedron Lett. 1998, 39, 3815-3818. - The synthesis of novel structural analogues of sialyl Lewis.
P V Murphy, R E Hubbard, D T Manallack, J G Montana and R J K Taylor Tetrahedron Lett. 1998, 39, 3273-3276.
1997
- Novel tandem conjugate addition-Ramberg-Bäcklund rearrangements.
P Evans and R J K Taylor Synlett 1997, 1043-1044. - Ketone homologation to produce alpha-methoxyketones: application to conduritol synthesis.
N Phillipson, M S Anson, J G Montana and R J K Taylor J. Chem. Soc. Perkin Trans. 1 1997, 2821-2829. - Organolithium additions to styrene derivatives .4. Tandem intermolecular-intramolecular carbolithiation as a new route to tetralins.
X D Wei and R J K Taylor Tetrahedron Lett. 1997, 38, 6467-6470. - Efficient conditions for the palladium(II) mediated coupling of organostannanes: The synthesis of 1,3-dienes, 1,4-dienes,1,3-diynes and biphenyls.
L Alcaraz and R J K Taylor Synlett 1997, 791-792. - The first preparation of episulfones from episulfides: Oxidation using Oxone(R) / trifluoroacetone.
P Johnson and R J K Taylor Tetrahedron Lett. 1997, 38, 5873-5876. - p-Di-t-butoxybenzene.
R M Carman, N Kanizaj and R J K Taylor Aust. J. Chem. 1997, 50, 515-516. - The epoxy-Ramberg-Bäcklund reaction: A new route to allylic alcohols.
P Evans and R J K Taylor Tetrahedron Lett. 1997, 38, 3055-3058. - Synthesis of tricholomenyn A and epitricholomenyn A by a palladium-catalysed beta-halo enone coupling route.
A E Graham and R J K Taylor J. Chem. Soc. Perkin Trans. 1 1997, 1087-1089. - N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate.
E F Evans, N J Lewis, I Kapfer, G Macdonald and R J K Taylor Synth. Commun. 1997, 27, 1819-1825. - Acetal and ketal deprotection using montmorillonite K10: The first synthesis of syn-4,8-dioxatricyclo[5.1.0.0(3,5)]-2,6-octanedione.
E C L Gautier, A E Graham, A McKillop, S P Standen and R J K Taylor Tetrahedron Lett. 1997, 38, 1881-1884. - Organolithium additions to styrene derivatives .3. Enantioselective routes to 2-arylalkanoic acids.
X D Wei and R J K Taylor Tetrahedron Asymm. 1997, 8, 665-668.
1996
- The synthesis and use of a N-15 and H-2 isotopically-labelled derivative of the spin-trap 3,5-dibromo-4-nitrosobenzenesulphonic acid.
G S Timmins, X Wei, C L Hawkins, R J K Taylor and M J Davies Redox Rep. 1996, 2, 407-410. - A Stille approach to unsaturated amides derived from 2-amino-3-hydroxycyclopentenone: The synthesis of asuka-mABA and limocrocin.
G Macdonald, N J Lewis and R J K Taylor Chem. Commun. 1996, 2647-2648. - Sonogashira coupling reactions of highly oxygenated vinyl halides: The first synthesis of harveynone and epi-harveynone.
A E Graham, D McKerrecher, D H Davies and R J K Taylor Tetrahedron Lett. 1996, 37, 7445-7448. - Amino acid derived thiane oxide and dioxide systems as disposable templates: Synthesis of alpha-amino ketones, anti-amino alcohols and an amino cyclopentenone.
M P Gamble, G M P Giblin, J G Montana, P O'Brien, T P Ockendon and R J K Taylor Tetrahedron Lett. 1996, 37, 7457-7460. - The preparation of 4-substituted pyrylium salts and their use in dienal synthesis.
P Charoenying, K Hemming, D McKerrecher and R J K Taylor J. Het. Chem. 1996, 33, 1083-1089. - The first total synthesis of a member of the manumycin family of antibiotics: Alisamycin.
L Alcaraz, G Macdonald, I Kapfer, N J Lewis and R J K Taylor Tetrahedron Lett. 1996, 37, 6619-6622. - Organolithium additions to styrene are synthetically viable.
X D Wei and R J K Taylor Chem. Commun. 1996, 187-188. - Glycosylation reactions of 2,3,4-tri-O-chlorosulfonyl-beta-L-fucopyranosyl chloride and 2,3,4-tri-O-chlorosulfonyl-beta-D-xylopyranosyl chloride.
R E Hubbard, J G Montana, P V Murphy and R J K Taylor Carbohyd. Res. 1996, 287, 247-253. - The total synthesis of the diepoxycyclohexanone antibiotic aranorosin and novel synthetic analogues.
A McKillop, L McLaren, R J K Taylor, R J Watson and N J Lewis J. Chem. Soc. Perkin Trans. 1 1996, 1385-1393. - Organolithium additions to styrene derivatives: Intramolecular alkylation processes.
X D Wei and R J K Taylor Tetrahedron Lett. 1996, 37, 4209-4210. - The generation and synthetic applications of episulfone alpha-anions.
A E Graham, W A Loughlin, M H Moore, S M Pyke, G Wilson and R J K Taylor J. Chem. Soc. Perkin Trans. 1 1996, 661-667. - The synthesis of novel analogues of the manumycin family of antibiotics and the antitumour antibiotic LL-C10037 alpha.
I Kapfer, N J Lewis, G Macdonald and R J K Taylor Tetrahedron Lett. 1996, 37, 2101-2104. - A new stereocontrolled, pyrylium-based route to conjugated dienynes: The first synthesis of Carduusyne A.
P Charoenying, H Davies, D McKerrecher and R J K Taylor Tetrahedron Lett. 1996, 37, 1913-1916. - The preparation of 9-substituted Delta 5-octenolides: Synthesis of 8-deoxy-pseudo-ascidiatrienolide C.
G A McNaughton-Smith and R J K Taylor Tetrahedron 1996, 52, 2113-2
1995
- Zirconium-Mediated Cyclisation Reactions of 2-Butenylstyrenes and Related Dienes, Enynes, and Dienes.
A J Bird, R J K Taylor and X Wei, Synlett, 1995, 1237 - The synthesis of trans-carbovir via the ramberg-bäcklund reaction.
A Grumann, H Marley and R J K Taylor, Tetrahedron Lett., 1995, 36, 7767. - Amino Acid Derived Sulfones for Chiral Cyclopentane Synthesis.
M P Gamble, G M P Giblin and R J K Taylor, Synlett, 1995, 779. - Pyrylium salts in polyene natural product synthesis: organometallic additions to 4-methylpyrylium tetrafluoroborate.
R J K Taylor, K Hemming and E F De Medeiros, J. Chem. Soc., Perkin Trans. 1, 1995, 2385. - (Halogenomethyl)phenyl α-D-glucopyranosides as enzyme-activated irreversible inhibitors of yeast α-glucosidase and potential anti-HIV agents.
J C Briggs, A H Haines and R J K Taylor, J. Chem. Soc., Perkin Trans. 1, 1995, 27. - A Simple and Efficient Procedure for the Preparation of Chiral 2-Oxazolidinones from agr-Amino Acids.
A McKillop, R J K Taylor, R J Watson and N Lewis, Synth. Commun., 1995, 25, 561.
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