Economic Evaluation Seminar - Model for the economic evaluation of interventions to manage neuropathic ulcers arising from leprosy and application to an intervention

Event details

Authors: Jessica Ochalek, Naomi Gibbs, Indra Bahadur Napit, Dilip Shrestha, Richard Lilford, Mark Sculpher

Abstract: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, continues to pose significant public health challenges, particularly in low- and middle-income countries (LMIC).  Despite extensive global efforts to control and eliminate the disease, leprosy remains endemic in several regions, with thousands of new cases reported annually.  One of the most debilitating complications of leprosy is the development of neuropathic ulcers, which result from the extensive nerve damage characteristic of the disease.  

Assessing whether interventions to treat or prevent leprosy ulcers offer good value for money requires modelling the lifetime costs and benefits resulting from these interventions and consideration of the opportunity cost of funding the intervention.  We develop a Markov model following the natural history of leprosy ulcers and demonstrate how the model can be used to provide policymakers, healthcare providers, and stakeholders with robust evidence to support informed decision-making in the management of leprosy-related ulcers in LMICs.  This is demonstrated by applying the model to assess the cost-effectiveness of Leukocyte-Platelet Rich Fibrin (L-PRF), a second-generation platelet concentrate which promotes healing and tissue regeneration.  Our analysis of L-PRF draws upon a recent trial undertaken in Nepal.

If you are not a member of University of York staff and are interested in attending a seminar, please contact shainur.premji@york.ac.uk or alfredo.palacios@york.ac.uk so that we can ensure we have sufficient space.

Jessica Ochalek, CHE

Jessica Ochalek