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Dr Pegine Walrad
Senior Lecturer in Molecular Parasitology

Biography

Dr Pegine Walrad is a Medical Research Council-funded Senior Lecturer (Associate Professor) in the York Biomedical Research Institute (YBRI) at the University of York and a global research leader in gene regulation and infectious disease. The Walrad lab investigates parasite genetics, cell biology and host:parasite interactions; with a focus upon RNA binding proteins in Kinteoplastid parasites that cause neglected tropical disease. She characterized conserved protein domains and isolated interacting partners of the transcription factor Runt (Runx), discovered the first trans-regulator of surface proteins and an essential, novel pathway of mRNA export in Trypanosomes that cause Sleeping Sickness (Walrad et al, MBC, 2010, 2011, Walrad et al. PLoS Pathogens, 2009, Walrad et al. NAR, 2012, Bühlmann et al. NAR, 2015). Parasite gene regulatory networks are divergent from humans and represent an untapped weakness to explore novel combative strategies and streamline diagnostics.

The Walrad lab has quantitatively identified the mRNA binding and whole cell proteomes of L. mexicana, identified key RBPs essential to mammalian infection, uncovered epigenetic regulation of Leishmania virulence by methylation of RNA binding protein (RBP) regulators (novel eukaryotic post-transcriptional epigenetics) and quantitatively defined motility dynamics of Leishmania and chemotaxis in human-infectious forms (Pablos et al. MCP, 2019, Parry, Teles et al. unpublished, Ferreira et al. NAR, 2020, Findlay et al. eLife, 2021).

Her research focuses on molecular pathways of the parasite lifecycle progression to human-infectious forms employing a range of multidisciplinary tools and approaches including molecular genetics, microfluidics, structural biophysics, bioinformatics and mathematical modeling of developmental events and transmission potential. Recent collaborations isolated a novel RBP master regulator of T.brucei differentiation in the tsetse fly, quantitatively identified the comprehensive RNA binding proteome of T. cruzi, verified and characterised novel ncRNA function in L.major and L.braziliensis and developed a mathematical model of L.mexicana transmission by sandflies (Casas-Sanchez et al. unpublished, Viraque et al. unpublished, Espada et al. unpublished, Quilles et al. unpublished, Teles et al. unpublished, Carmichael et al. PLoS NTD, 2021).The Walrad lab collaborates with multiple international consortiums (NTD Network, LeishPathNet, JCPiL, Leish@York) and is supported by the UK Medical Research Council, FAPESP, CNPq (Science without Borders), Royal Society, and Horizon Europe’s Global Health EDCTP3. 

A strong advocate for EDI, she is Athena Swan lead for the Department of Biology at York, England’s 1st Gold Award recipient. She officially mentors a full range of career researchers, from undergraduates to junior academics. She is Protozoan Subject Editor for Parasites and Vectors journal. She has Co-chaired and been the Main Organiser of Europe’s foremost international conference in Parasitology (2021, 2022), expanding its reach through hybrid delivery, elevating York’s visibility as a leading global hub. In 2021 as EDI advisor for the British Society for Parasitology’s Executive Council, Dr. Walrad  initiated, realised and established obligatory free childcare, ECR career and Diversity and Inclusion sessions at all international BSP meetings. During her tenure global membership expanded from ~20 countries to 53.  

Contact details

Pegine Walrad
Senior Lecturer in Molecular Parasitology
University of York

@pegsparasites