Publications
Selected publications
MacDonald SJ, Thomas GH, Douglas AE (2011)
Genetic and
metabolic determinants of nutritional phenotype in an
insect-bacterial symbiosis.
Mol Ecol. 2011
20(10):2073-84.
Severi E, Müller A, Potts JR, Leech A, Williamson D, Wilson KS and Thomas GH (2008) Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT
J Biol Chem 283: 4841-9
Thomas GH, Zucker J, Macdonald SJ, Sorokin A, Goryanin I, Douglas AE (2009) A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola.
BMC Syst Biol 3: 24
Mulligan C, Geertsma ER, Severi E, Kelly DJ, Poolman B, Thomas GH (2009) The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter.
Proc Natl Acad Sci U S A.
106(6): 1778-83.
Full publications list
2011
MacDonald SJ, Thomas GH, Douglas AE (2011) Genetic and
metabolic determinants of nutritional phenotype in an
insect-bacterial symbiosis. Mol Ecol. 2011
20(10):2073-84.
Maqbool, A., Levdikov, V.M., Blagova, E., Herve, M., Horler,
R.S.P., Wilkinson, A.J. and Thomas, G.H. (2011) Compensating
stereochemical changes allow murein tripeptide to be
accommodated in a conventional peptide binding protein
J. Biol. Chem. jbc.M111.267179. First Published on June 24,
2011, doi:10.1074/jbc.M111.267179.
2010
Fischer, M., Zhang, Q.Y., Hubbard, R.E. and Thomas G.H. (2010) Caught in a TRAP: substrate binding proteins in secondary transport.
Trends in Microbiology. in press.
Mulligan, C., Fischer, M. and Thomas G.H. (2010) Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea.
FEMS Microbiology Reviews May 28. [Epub ahead of print].
The International Aphid Genomics Consortium (2010) Genome Sequence of the Pea Aphid
Acyrthosiphon pisum.
PLoS Biol
8(2):e1000313.
Wilson ACC, Ashton PD, Calevro F, Charles H, Colella S, Febvay G, Jander G, Kushlan P, Macdonald SA, Schwartz J, Thomas GH and Douglas AE (2010) Genomic insight into the amino acid relations of the pea aphid
Acyrthosiphon pisum with its symbiotic bacterium
Buchnera aphidicola.
Insect Molecular Biology 19 (Suppl. 2), 249–258.
Ramsey JS, MacDonald SJ, Jander G, Nakabachi A, Thomas GH and Douglas AE (2010) Genomic evidence for complementary purine metabolism in the pea aphid
Acyrthosiphon pisum and its symbiotic bacterium
Buchnera aphidicola.
Insect Molecular Biology 19 (Suppl. 2), 241–248.
Severi, E., Hosie, A.H.F., Hawkhead, J., and Thomas G.H. (2010) Characterisation of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters.
FEMS Microbiolgy Letters.
304:47-54.
2009
Jackson, A.P., Thomas, G.H., Parkhill, J. and Thomson, N.R. (2009) Evolutionary diversification of an ancient gene family (Rhs) through C-terminal displacement.
BMC Genomics 10(1):584.
Thomas, G.H. (2009) Homes for the orphans: utilization of multiple substrate binding proteins by ABC transporters.
Mol Microbiol.
Horler, R.S.P., Müller, A., Williamson, D.C., Potts, J.R., Wilson, K.S. and Thomas GH (2009) Furanose-specific sugar transport: characterisation of a bacterial galactofuranose binding protein.
J. Biol. Chem.
284(45):31156-63.
Basavanna S, Khandavilli S, Yuste J, Cohen JM, Hosie AH, Webb AJ, Thomas GH, Brown JS (2009) Screening of
Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis.
Infect Immun.
77(8):3412-23.
Thomas GH, Zucker J, Macdonald SJ, Sorokin A, Goryanin I, Douglas AE (2009) A fragile metabolic network adapted for cooperation in the symbiotic bacterium
Buchnera aphidicola. BMC Syst Biol.
3:24.
Mulligan C, Geertsma ER, Severi E, Kelly DJ, Poolman B, Thomas GH (2009) The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter.
Proc Natl Acad Sci U S A.
106(6):1778-83.
Md-Saleh SR, Chilvers EC, Kerr KG, Milner SJ, Snelling AM, Weber JP, Thomas GH, Duhme-Klair AK, Routledge A. (2009) Synthesis of citrate-ciprofloxacin conjugates.
Bioorg Med Chem Lett.
19(5):1496-8.
Horler RS, Butcher A, Papangelopoulos N, Ashton PD, Thomas GH (2009) EchoLOCATION: an in silico analysis of the subcellular locations of
Escherichia coli proteins and comparison with experimentally derived locations.
Bioinformatics.
25(2):163-6.
2008
Severi, E., Müller, A., Potts, JR., Leech, A., Williamson, D., Wilson, KS and Thomas GH (2008) Sialic acid mutarotation is catalysed by the
Escherichia coli beta-propeller protein YjhT.
J. Biol. Chem.
283:4841-9.
2007
Severi, E, Hood, DW and Thomas GH. (2007) Sialic acid utilization by bacterial pathogens.
Microbiology 153:2817-22.
Mulligan, C., Kelly, D.J. and Thomas, G.H. (2007) Tripartite ATP-Independent Periplasmic Transporters: Application of a Relational Database for Genome-Wide Analysis of Transporter Gene Frequency and Organization.
J Mol Microbiol Biotechnol.
12:218-26.
Chaudhuri R.R. and Thomas G.H. (2007) Understanding the Model and the Menace: a Postgenomic View of
Escherichia coli. In Bacterial Pathogenomics. Edited by Mark J. Pallen, M.J., Nelson, K.E. and Preston, G.M. ASM Press May 2007.
Thomas GH (2007) Napoleon and typhus: a tale of two generals.
Microbiology Today Feb 2007.
2006
Muller, A., Severi, E., Mulligan, C., Watts, A.G., Kelly, D.J., Wilson, K.S., Wilkinson, A.J. and Thomas GH. (2006) Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from
Haemophilus influenzae. J Biol Chem.
281:22212-22.
Riley, M., Abe, T., Arnaud, M.B., Berlyn, M.K., Blattner, F.R., Chaudhuri, R.R., Glasner, J.D., Horiuchi, T., Keseler, I.M., Kosuge, T., Mori, H., Perna, N.T., Plunkett, G. 3rd, Rudd, K.E., Serres, M.H. and Thomas, G.H., Thomson, N.R., Wishart, D. and Wanner, B.L. (2006)
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005.
Nucleic Acids Res.
34:1-9.
Prickett, M.D., Page, M., Douglas, A.E. and Thomas GH. (2006) BuchneraBASE: a post-genomic resource for
Buchnera sp. APS.
Bioinformatics. 22:641-2.
Thomas GH, Southworth T, Leon-Kempis MR, Leech A, Kelly DJ. (2006) Novel ligands for the extracellular solute receptors of two bacterial TRAP transporters.
Microbiology.
152:187-98.
2005
Severi, E., Randle, G., Kivlin, P., Whitfield, K., Young, R., Moxon, R., Kelly, D., Hood, D. and Thomas, G.H. (2005) Sialic acid transport in
Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter.
Mol Microbiol.
58:1173-85.
Muller, A., Thomas, G.H., Horler, R., Brannigan, J.A., Blagova, E., Levdikov, V.M., Fogg, M.J., Wilson, K.S. and Wilkinson, A.J. (2005) An ATP-binding cassette-type cysteine transporter in
Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein.
Mol Microbiol. 57:143-55.
Thomas, G.H. (2005) The nicer side of
E. coli: Escherichia coli as a model organism.
The Biochemist. Dec 2005.
Thomas, G.H. (2005) Microbes in the air: John Tyndall and the spontaneous generation debate.
Microbiology Today. Nov 2005.