Experimental evolution of cancer cell lines

The methods of experimental evolution can be used to understand cancer progression. We evolved cancer cell lines in vitro, simulating three important stages of metastasis: escape from a primary tumour, invasion of a distant site, and colonisation of lung tissue. Computer vision revealed phenotypic differences between the cell lines - in particular, cells evolved for colonisation showed unique behavioural patterns. Techniques like these could help identify the phenotypes that determine metastatic ability.

The seminar will be hosted using Zoom. A Google calendar invite featuring the Zoom link will be sent to Biology staff and students before the seminar date. For all enquiries please contact Biology DMT Hub.