Spindle Assembly Checkpoint Silencing: MPS1 regulation at the kinetochore

Faithful segregation of sister chromatids during mitosis is essential for successful cell division. The Spindle Assembly Checkpoint halts mitotic progression until all kinetochores of sister chromatids are attached to microtubules from opposite poles. How the Spindle Assembly Checkpoint recognises microtubule attachment at the kinetochore and is subsequently silenced has long been an important unresolved question. By focusing on the regulation of MPS1 kinase, the master upstream controller of the Spindle Assembly Checkpoint, we have elucidated the roles of multiple kinases and phosphatases in modulating Spindle Assembly Checkpoint activity during mitosis, and have established the key factors essential for Spindle Assembly Checkpoint silencing.

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