Mechanism of ATP and PMF driven protein transport through the bacterial envelope

My talk will focus on the essential role of the Sec machinery for protein secretion, membrane protein and outer membrane protein (OMP) transport. I will summarise progress made towards our understanding of the mechanism of protein translocation; first of all, across the inner membrane. This will include the molecular basis for ATP and PMF driven protein transport. I will also describe how proteins emerging from the Sec translocon could be transported though the periplasm to the BAM machinery for OMP folding and membrane insertion.