Accessibility statement

Containment of Organisms with a Gene Drive

Some strategies of containment:

  • Molecular:
    • Place drive components Cas9 and guide RNA at different loci (‘split drive’)
    • Use target sequences unique for lab strain
  • Ecological:
    • Perform experiments in area where wild species does not exist
    • Use lab strain that cannot reproduce with wild strain
  • Physical:
    • Barriers between organisms and the environment (triple)
    • Remove barrier only when organism is inactive
    • Take precautions to prevent breaches due to human errors