Lesley Schatzberger has been at the forefront of historical instrument performance while also remaining active in a broad range of music making. After studying at the junior department of the Royal Manchester College of Music, she went on to the University of York, and then for postgraduate studies to the Royal Academy of Music. She was appointed as principal clarinet with Roger Norrington's London Classical Players, John Eliot Gardiner's English Baroque Soloists and Orchestre Révolutionnaire et Romantique. She has toured many times in Europe, the United States, and Japan, including performances with Stockhausen's chamber ensemble and with the Academy of Ancient Music.
Lesley taught at the Royal Northern College of Music and founded Jessie's Fund, a charity helping seriously ill children through music, which was established in memory of her daughter. In 2006 she was awarded an honorary doctorate by the University of York, and in 2021 she was conferred Honorary Membership by the Royal Northern College of Music.